Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

Global transcriptional differences across lobular units in the liver remain unknown. Here the authors perform spatial transcriptomics of liver tissue to delineate transcriptional differences in physical space, confirm lobular zonation along transcriptional gradients and suggest the presence of previ...

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Autores principales:	Franziska Hildebrandt, Alma Andersson, Sami Saarenpää, Ludvig Larsson, Noémi Van Hul, Sachie Kanatani, Jan Masek, Ewa Ellis, Antonio Barragan, Annelie Mollbrink, Emma R. Andersson, Joakim Lundeberg, Johan Ankarklev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/086d1b20b6b745fca94bbab34b162566
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spelling	oai:doaj.org-article:086d1b20b6b745fca94bbab34b1625662021-12-05T12:23:08ZSpatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver10.1038/s41467-021-27354-w2041-1723https://doaj.org/article/086d1b20b6b745fca94bbab34b1625662021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27354-whttps://doaj.org/toc/2041-1723Global transcriptional differences across lobular units in the liver remain unknown. Here the authors perform spatial transcriptomics of liver tissue to delineate transcriptional differences in physical space, confirm lobular zonation along transcriptional gradients and suggest the presence of previously uncharacterized structures within liver tissue.Franziska HildebrandtAlma AnderssonSami SaarenpääLudvig LarssonNoémi Van HulSachie KanataniJan MasekEwa EllisAntonio BarraganAnnelie MollbrinkEmma R. AnderssonJoakim LundebergJohan AnkarklevNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Franziska Hildebrandt Alma Andersson Sami Saarenpää Ludvig Larsson Noémi Van Hul Sachie Kanatani Jan Masek Ewa Ellis Antonio Barragan Annelie Mollbrink Emma R. Andersson Joakim Lundeberg Johan Ankarklev Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
description	Global transcriptional differences across lobular units in the liver remain unknown. Here the authors perform spatial transcriptomics of liver tissue to delineate transcriptional differences in physical space, confirm lobular zonation along transcriptional gradients and suggest the presence of previously uncharacterized structures within liver tissue.
format	article
author	Franziska Hildebrandt Alma Andersson Sami Saarenpää Ludvig Larsson Noémi Van Hul Sachie Kanatani Jan Masek Ewa Ellis Antonio Barragan Annelie Mollbrink Emma R. Andersson Joakim Lundeberg Johan Ankarklev
author_facet	Franziska Hildebrandt Alma Andersson Sami Saarenpää Ludvig Larsson Noémi Van Hul Sachie Kanatani Jan Masek Ewa Ellis Antonio Barragan Annelie Mollbrink Emma R. Andersson Joakim Lundeberg Johan Ankarklev
author_sort	Franziska Hildebrandt
title	Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
title_short	Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
title_full	Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
title_fullStr	Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
title_full_unstemmed	Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
title_sort	spatial transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/086d1b20b6b745fca94bbab34b162566
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Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

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