Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum

Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a major public health problem worldwide. Recent increases in the number of syphilis cases, in addition to the lack of an efficient vaccine against T. pallidum for humans, highlights an urgent need for the desi...

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Autores principales:	Man Xu, Yafeng Xie, Kang Zheng, Haodang Luo, Manyi Tan, Feijun Zhao, Tiebing Zeng, Yimou Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Treponema pallidum Tp0136 Tp0663 vaccine candidate dissemination Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/086dbbb70d5a437a9878ef13ecbd470a
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spelling	oai:doaj.org-article:086dbbb70d5a437a9878ef13ecbd470a2021-12-01T03:04:21ZTwo Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum1664-322410.3389/fimmu.2021.759474https://doaj.org/article/086dbbb70d5a437a9878ef13ecbd470a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.759474/fullhttps://doaj.org/toc/1664-3224Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a major public health problem worldwide. Recent increases in the number of syphilis cases, in addition to the lack of an efficient vaccine against T. pallidum for humans, highlights an urgent need for the design and development of an efficacious syphilis vaccine. Here, we assess the vaccine potential of the adhesion protein Tp0136 and the outer membrane protein Tp0663. Rabbits were subcutaneously immunized with recombinant proteins Tp0136, Tp0663, or control PBS. Immunization with Tp0136 or Tp0663 generated a strong humoral immune response with high titers of IgG, as assessed by ELISA. Moreover, animals immunized with Tp0136 or Tp0663 exhibited attenuated lesion development, increased cellular infiltration at the lesion sites, and inhibition of treponemal dissemination to distant organs compared to the unimmunized animals. These findings indicate that Tp0136 and Tp0663 are promising syphilis vaccine candidates. Furthermore, these results provide novel and important information for not only understanding the pathogenic mechanisms of spirochetes, but also the development of spirochete-specific subunit vaccines.Man XuMan XuYafeng XieYafeng XieYafeng XieKang ZhengHaodang LuoManyi TanFeijun ZhaoFeijun ZhaoTiebing ZengTiebing ZengYimou WuYimou WuFrontiers Media S.A.articleTreponema pallidumTp0136Tp0663vaccine candidatedisseminationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Treponema pallidum Tp0136 Tp0663 vaccine candidate dissemination Immunologic diseases. Allergy RC581-607
spellingShingle	Treponema pallidum Tp0136 Tp0663 vaccine candidate dissemination Immunologic diseases. Allergy RC581-607 Man Xu Man Xu Yafeng Xie Yafeng Xie Yafeng Xie Kang Zheng Haodang Luo Manyi Tan Feijun Zhao Feijun Zhao Tiebing Zeng Tiebing Zeng Yimou Wu Yimou Wu Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum
description	Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a major public health problem worldwide. Recent increases in the number of syphilis cases, in addition to the lack of an efficient vaccine against T. pallidum for humans, highlights an urgent need for the design and development of an efficacious syphilis vaccine. Here, we assess the vaccine potential of the adhesion protein Tp0136 and the outer membrane protein Tp0663. Rabbits were subcutaneously immunized with recombinant proteins Tp0136, Tp0663, or control PBS. Immunization with Tp0136 or Tp0663 generated a strong humoral immune response with high titers of IgG, as assessed by ELISA. Moreover, animals immunized with Tp0136 or Tp0663 exhibited attenuated lesion development, increased cellular infiltration at the lesion sites, and inhibition of treponemal dissemination to distant organs compared to the unimmunized animals. These findings indicate that Tp0136 and Tp0663 are promising syphilis vaccine candidates. Furthermore, these results provide novel and important information for not only understanding the pathogenic mechanisms of spirochetes, but also the development of spirochete-specific subunit vaccines.
format	article
author	Man Xu Man Xu Yafeng Xie Yafeng Xie Yafeng Xie Kang Zheng Haodang Luo Manyi Tan Feijun Zhao Feijun Zhao Tiebing Zeng Tiebing Zeng Yimou Wu Yimou Wu
author_facet	Man Xu Man Xu Yafeng Xie Yafeng Xie Yafeng Xie Kang Zheng Haodang Luo Manyi Tan Feijun Zhao Feijun Zhao Tiebing Zeng Tiebing Zeng Yimou Wu Yimou Wu
author_sort	Man Xu
title	Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum
title_short	Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum
title_full	Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum
title_fullStr	Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum
title_full_unstemmed	Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum
title_sort	two potential syphilis vaccine candidates inhibit dissemination of treponema pallidum
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/086dbbb70d5a437a9878ef13ecbd470a
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Two Potential Syphilis Vaccine Candidates Inhibit Dissemination of Treponema pallidum

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