Current approaches to the treatment of Parkinson’s disease
Joseph Jankovic, L Giselle AguilarParkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of MedicineAbstract: Enormous progress has been made in the treatment of Parkinson’s disease (PD). As a result of advances in experimental t...
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Dove Medical Press
2008
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oai:doaj.org-article:086edf1cfa7b4c08907f4b7f18646a8e2021-12-02T02:12:40ZCurrent approaches to the treatment of Parkinson’s disease1176-63281178-2021https://doaj.org/article/086edf1cfa7b4c08907f4b7f18646a8e2008-09-01T00:00:00Zhttp://www.dovepress.com/current-approaches-to-the-treatment-of-parkinsonrsquos-disease-a2200https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Joseph Jankovic, L Giselle AguilarParkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of MedicineAbstract: Enormous progress has been made in the treatment of Parkinson’s disease (PD). As a result of advances in experimental therapeutics, many promising therapies for PD are emerging. Levodopa remains the most potent drug for controlling PD symptoms, yet is associated with significant complications such as the “wearing off” effect, levodopa-induced dyskinesias and other motor complications. Catechol-o-methyl-transferase inhibitors, dopamine agonists and nondopaminergic therapy are alternative modalities in the management of PD and may be used concomitantly with levodopa or one another. The neurosurgical treatment, focusing on deep brain stimulation, is reviewed briefly. Although this review has attempted to highlight the most recent advances in the treatment of PD, it is important to note that new treatments are not necessarily better than the established conventional therapy and that the treatment options must be individualized and tailored to the needs of each individual patient.Keywords: Parkinson’s disease, levodopa, medical treatment, pallidotomy, deep brain stimulation Joseph JankovicL Giselle AguilarDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 4, Pp 743-757 (2008) |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Joseph Jankovic L Giselle Aguilar Current approaches to the treatment of Parkinson’s disease |
| description |
Joseph Jankovic, L Giselle AguilarParkinson’s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of MedicineAbstract: Enormous progress has been made in the treatment of Parkinson’s disease (PD). As a result of advances in experimental therapeutics, many promising therapies for PD are emerging. Levodopa remains the most potent drug for controlling PD symptoms, yet is associated with significant complications such as the “wearing off” effect, levodopa-induced dyskinesias and other motor complications. Catechol-o-methyl-transferase inhibitors, dopamine agonists and nondopaminergic therapy are alternative modalities in the management of PD and may be used concomitantly with levodopa or one another. The neurosurgical treatment, focusing on deep brain stimulation, is reviewed briefly. Although this review has attempted to highlight the most recent advances in the treatment of PD, it is important to note that new treatments are not necessarily better than the established conventional therapy and that the treatment options must be individualized and tailored to the needs of each individual patient.Keywords: Parkinson’s disease, levodopa, medical treatment, pallidotomy, deep brain stimulation |
| format |
article |
| author |
Joseph Jankovic L Giselle Aguilar |
| author_facet |
Joseph Jankovic L Giselle Aguilar |
| author_sort |
Joseph Jankovic |
| title |
Current approaches to the treatment of Parkinson’s disease |
| title_short |
Current approaches to the treatment of Parkinson’s disease |
| title_full |
Current approaches to the treatment of Parkinson’s disease |
| title_fullStr |
Current approaches to the treatment of Parkinson’s disease |
| title_full_unstemmed |
Current approaches to the treatment of Parkinson’s disease |
| title_sort |
current approaches to the treatment of parkinson’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/086edf1cfa7b4c08907f4b7f18646a8e |
| work_keys_str_mv |
AT josephjankovic currentapproachestothetreatmentofparkinsonamprsquosdisease AT lgiselleaguilar currentapproachestothetreatmentofparkinsonamprsquosdisease |
| _version_ |
1718402570670571520 |