Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals
Abstract We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-mediated vasodilation (FMD) and nitroglycerin...
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Nature Portfolio
2017
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oai:doaj.org-article:086ee88cd92448e982a06566e24945f02021-12-02T11:40:23ZOptimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals10.1038/s41598-017-09043-12045-2322https://doaj.org/article/086ee88cd92448e982a06566e24945f02017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09043-1https://doaj.org/toc/2045-2322Abstract We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) were inversely correlated with LDL-C in the 957 statin naïve subjects but not in the 392 subjects receiving statin therapy. In statin naïve subjects, non-high LDL-C (≤100 mg/dL) was independently associated with a decrease in adjusted odds ratio of the low tertile of FMD (OR: 0.62, 95% CI: 0.45–0.85; P = 0.003) and NID (OR: 0.69, 95% CI: 0.50–0.96; P = 0.03). Adjusted odds ratio of the low tertile of FMD was significantly lower in the low LDL-C group (≤70 mg/dL) (OR: 0.47, 95% CI, 0.27–0.81; P = 0.006) and in the moderate LDL-C group (70.1–100 mg/dL) (OR: 0.66, 95% CI, 0.48–0.94; P = 0.02) than in the high LDL-C group (>100 mg/dL). There was no significant difference in FMD between the low LDL-C group and moderate LDL-C group. There were significant relationships of FMD and NID with LDL-C levels in statin naïve subjects. In a general population, LDL-C of ≤100 mg/dL may be the optimal target level for maintenance of endothelial function.Shogo MatsuiMasato KajikawaEisuke HidaTatsuya MaruhashiYumiko IwamotoAkimichi IwamotoNozomu OdaShinji KishimotoTakayuki HidakaYasuki KiharaKazuaki ChayamaChikara GotoYoshiki AibaraAyumu NakashimaFarina Binti Mohamad YusoffKensuke NomaYukihito HigashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Shogo Matsui Masato Kajikawa Eisuke Hida Tatsuya Maruhashi Yumiko Iwamoto Akimichi Iwamoto Nozomu Oda Shinji Kishimoto Takayuki Hidaka Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Ayumu Nakashima Farina Binti Mohamad Yusoff Kensuke Noma Yukihito Higashi Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| description |
Abstract We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) were inversely correlated with LDL-C in the 957 statin naïve subjects but not in the 392 subjects receiving statin therapy. In statin naïve subjects, non-high LDL-C (≤100 mg/dL) was independently associated with a decrease in adjusted odds ratio of the low tertile of FMD (OR: 0.62, 95% CI: 0.45–0.85; P = 0.003) and NID (OR: 0.69, 95% CI: 0.50–0.96; P = 0.03). Adjusted odds ratio of the low tertile of FMD was significantly lower in the low LDL-C group (≤70 mg/dL) (OR: 0.47, 95% CI, 0.27–0.81; P = 0.006) and in the moderate LDL-C group (70.1–100 mg/dL) (OR: 0.66, 95% CI, 0.48–0.94; P = 0.02) than in the high LDL-C group (>100 mg/dL). There was no significant difference in FMD between the low LDL-C group and moderate LDL-C group. There were significant relationships of FMD and NID with LDL-C levels in statin naïve subjects. In a general population, LDL-C of ≤100 mg/dL may be the optimal target level for maintenance of endothelial function. |
| format |
article |
| author |
Shogo Matsui Masato Kajikawa Eisuke Hida Tatsuya Maruhashi Yumiko Iwamoto Akimichi Iwamoto Nozomu Oda Shinji Kishimoto Takayuki Hidaka Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Ayumu Nakashima Farina Binti Mohamad Yusoff Kensuke Noma Yukihito Higashi |
| author_facet |
Shogo Matsui Masato Kajikawa Eisuke Hida Tatsuya Maruhashi Yumiko Iwamoto Akimichi Iwamoto Nozomu Oda Shinji Kishimoto Takayuki Hidaka Yasuki Kihara Kazuaki Chayama Chikara Goto Yoshiki Aibara Ayumu Nakashima Farina Binti Mohamad Yusoff Kensuke Noma Yukihito Higashi |
| author_sort |
Shogo Matsui |
| title |
Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_short |
Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_full |
Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_fullStr |
Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_full_unstemmed |
Optimal Target Level of Low-density Lipoprotein Cholesterol for Vascular Function in Statin Naïve Individuals |
| title_sort |
optimal target level of low-density lipoprotein cholesterol for vascular function in statin naïve individuals |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/086ee88cd92448e982a06566e24945f0 |
| work_keys_str_mv |
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