Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages

Receptor tyrosine kinases localize to the cell surface and have been suggested to also have nuclear function. Here the authors provide evidence that Colony Stimulating Factor-1 Receptor (CSF-1R) migrates to the nucleus upon CSF-1 stimulation in monocytes and that upon differentiation into macrophage...

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Auteurs principaux:	Laura Bencheikh, M’Boyba Khadija Diop, Julie Rivière, Aygun Imanci, Gerard Pierron, Sylvie Souquere, Audrey Naimo, Margot Morabito, Michaël Dussiot, Frédéric De Leeuw, Camille Lobry, Eric Solary, Nathalie Droin
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/087012bf40e543c99b57671485f865ff
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id	oai:doaj.org-article:087012bf40e543c99b57671485f865ff
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spelling	oai:doaj.org-article:087012bf40e543c99b57671485f865ff2021-12-02T15:36:02ZDynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages10.1038/s41467-019-09970-92041-1723https://doaj.org/article/087012bf40e543c99b57671485f865ff2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09970-9https://doaj.org/toc/2041-1723Receptor tyrosine kinases localize to the cell surface and have been suggested to also have nuclear function. Here the authors provide evidence that Colony Stimulating Factor-1 Receptor (CSF-1R) migrates to the nucleus upon CSF-1 stimulation in monocytes and that upon differentiation into macrophages, CSF-1R localizes to TSS, co-localizes with H3K4me3, and interacts with ELK and YY1.Laura BencheikhM’Boyba Khadija DiopJulie RivièreAygun ImanciGerard PierronSylvie SouquereAudrey NaimoMargot MorabitoMichaël DussiotFrédéric De LeeuwCamille LobryEric SolaryNathalie DroinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura Bencheikh M’Boyba Khadija Diop Julie Rivière Aygun Imanci Gerard Pierron Sylvie Souquere Audrey Naimo Margot Morabito Michaël Dussiot Frédéric De Leeuw Camille Lobry Eric Solary Nathalie Droin Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
description	Receptor tyrosine kinases localize to the cell surface and have been suggested to also have nuclear function. Here the authors provide evidence that Colony Stimulating Factor-1 Receptor (CSF-1R) migrates to the nucleus upon CSF-1 stimulation in monocytes and that upon differentiation into macrophages, CSF-1R localizes to TSS, co-localizes with H3K4me3, and interacts with ELK and YY1.
format	article
author	Laura Bencheikh M’Boyba Khadija Diop Julie Rivière Aygun Imanci Gerard Pierron Sylvie Souquere Audrey Naimo Margot Morabito Michaël Dussiot Frédéric De Leeuw Camille Lobry Eric Solary Nathalie Droin
author_facet	Laura Bencheikh M’Boyba Khadija Diop Julie Rivière Aygun Imanci Gerard Pierron Sylvie Souquere Audrey Naimo Margot Morabito Michaël Dussiot Frédéric De Leeuw Camille Lobry Eric Solary Nathalie Droin
author_sort	Laura Bencheikh
title	Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
title_short	Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
title_full	Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
title_fullStr	Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
title_full_unstemmed	Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
title_sort	dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/087012bf40e543c99b57671485f865ff
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Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages

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