Solid-phase synthesis of protein-polymers on reversible immobilization supports

Synthesis of protein-polymer conjugates typically relies on multi-step processes in solution and on challenging purification strategies. Here the authors show a robust synthesis approach which eliminates purification processes by immobilizing proteins reversibly on modified agarose beads before graf...

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Autores principales:	Hironobu Murata, Sheiliza Carmali, Stefanie L. Baker, Krzysztof Matyjaszewski, Alan J. Russell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08770c065c46456a829a399cd1350994
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spelling	oai:doaj.org-article:08770c065c46456a829a399cd13509942021-12-02T15:34:03ZSolid-phase synthesis of protein-polymers on reversible immobilization supports10.1038/s41467-018-03153-82041-1723https://doaj.org/article/08770c065c46456a829a399cd13509942018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03153-8https://doaj.org/toc/2041-1723Synthesis of protein-polymer conjugates typically relies on multi-step processes in solution and on challenging purification strategies. Here the authors show a robust synthesis approach which eliminates purification processes by immobilizing proteins reversibly on modified agarose beads before grafting from polymers via ATRP.Hironobu MurataSheiliza CarmaliStefanie L. BakerKrzysztof MatyjaszewskiAlan J. RussellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hironobu Murata Sheiliza Carmali Stefanie L. Baker Krzysztof Matyjaszewski Alan J. Russell Solid-phase synthesis of protein-polymers on reversible immobilization supports
description	Synthesis of protein-polymer conjugates typically relies on multi-step processes in solution and on challenging purification strategies. Here the authors show a robust synthesis approach which eliminates purification processes by immobilizing proteins reversibly on modified agarose beads before grafting from polymers via ATRP.
format	article
author	Hironobu Murata Sheiliza Carmali Stefanie L. Baker Krzysztof Matyjaszewski Alan J. Russell
author_facet	Hironobu Murata Sheiliza Carmali Stefanie L. Baker Krzysztof Matyjaszewski Alan J. Russell
author_sort	Hironobu Murata
title	Solid-phase synthesis of protein-polymers on reversible immobilization supports
title_short	Solid-phase synthesis of protein-polymers on reversible immobilization supports
title_full	Solid-phase synthesis of protein-polymers on reversible immobilization supports
title_fullStr	Solid-phase synthesis of protein-polymers on reversible immobilization supports
title_full_unstemmed	Solid-phase synthesis of protein-polymers on reversible immobilization supports
title_sort	solid-phase synthesis of protein-polymers on reversible immobilization supports
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/08770c065c46456a829a399cd1350994
work_keys_str_mv	AT hironobumurata solidphasesynthesisofproteinpolymersonreversibleimmobilizationsupports AT sheilizacarmali solidphasesynthesisofproteinpolymersonreversibleimmobilizationsupports AT stefanielbaker solidphasesynthesisofproteinpolymersonreversibleimmobilizationsupports AT krzysztofmatyjaszewski solidphasesynthesisofproteinpolymersonreversibleimmobilizationsupports AT alanjrussell solidphasesynthesisofproteinpolymersonreversibleimmobilizationsupports
_version_	1718386943778095104

Solid-phase synthesis of protein-polymers on reversible immobilization supports

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