A Single-Carbon Stable Isotope Ratio Model Prediction Equation Can Estimate Self-Reported Added Sugars Intake in an Adult Population Living in Southwest Virginia
The δ<sup>13</sup>C value of blood is a novel proposed biomarker of added sugars (AS) intake. AS prediction equations using either a single- (δ<sup>13</sup>C) or dual-isotope model (δ<sup>13</sup>C and δ<sup>15</sup>N) were previously developed in an a...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/087ab973d0fe45ebaae36b0578b370d7 |
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| Sumario: | The δ<sup>13</sup>C value of blood is a novel proposed biomarker of added sugars (AS) intake. AS prediction equations using either a single- (δ<sup>13</sup>C) or dual-isotope model (δ<sup>13</sup>C and δ<sup>15</sup>N) were previously developed in an adult population with high AS intake living in southwest Virginia (reference group). The purpose of this investigation was to test the δ<sup>13</sup>C single- and δ<sup>13</sup>C and δ<sup>15</sup>N dual-isotope prediction equations for AS intake in adults with a lower mean AS intake and different demographic characteristics (test group). The blood samples for the reference (<i>n</i> = 257 for single-isotope, <i>n</i> = 115 for dual-isotope) and test groups (<i>n</i> = 56) were analyzed for δ<sup>13</sup>C and δ<sup>15</sup>N values using natural abundance stable isotope mass spectrometry and were compared to reported dietary AS intake. When the δ<sup>13</sup>C single-isotope equation was applied to the test group, predicted AS intake was not significantly different from reported AS intake (mean difference ± standard error = −3.6 ± 5.5 g, Z = −0.55, <i>p</i> = 0.51). When testing the dual-isotope equation, predicted AS was different from reported AS intake (mean difference ± SEM = 13.0 ± 5.4 g, Z = −2.95, <i>p</i> = 0.003). δ<sup>13</sup>C value was able to predict AS intake using a blood sample within this population subset. The single-isotope prediction equation may be an alternative method to assess AS intake and is more objective, cost-feasible, and efficient than traditional dietary assessment methods. However, more research is needed to assess this biomarker with rigorous study designs such as controlled feeding. |
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