Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion

The gut microbiota can alter the effects of anticancer fluoropyrimidines such as 5-fluorodeoxyuridine (FUdR) in the model organism C. elegans. Here, the authors show that these effects are further affected by diet, and dietary thymidine and serine increase FUdR toxicity in C. elegans via different m...

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Autores principales:	Wenfan Ke, James A. Saba, Cong-Hui Yao, Michael A. Hilzendeger, Anna Drangowska-Way, Chintan Joshi, Vinod K. Mony, Shawna B. Benjamin, Sisi Zhang, Jason Locasale, Gary J. Patti, Nathan Lewis, Eyleen J. O’Rourke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/087ce5c3356748578c51b823b74c950a
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spelling	oai:doaj.org-article:087ce5c3356748578c51b823b74c950a2021-12-02T15:52:53ZDietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion10.1038/s41467-020-16220-w2041-1723https://doaj.org/article/087ce5c3356748578c51b823b74c950a2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16220-whttps://doaj.org/toc/2041-1723The gut microbiota can alter the effects of anticancer fluoropyrimidines such as 5-fluorodeoxyuridine (FUdR) in the model organism C. elegans. Here, the authors show that these effects are further affected by diet, and dietary thymidine and serine increase FUdR toxicity in C. elegans via different mechanisms.Wenfan KeJames A. SabaCong-Hui YaoMichael A. HilzendegerAnna Drangowska-WayChintan JoshiVinod K. MonyShawna B. BenjaminSisi ZhangJason LocasaleGary J. PattiNathan LewisEyleen J. O’RourkeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenfan Ke James A. Saba Cong-Hui Yao Michael A. Hilzendeger Anna Drangowska-Way Chintan Joshi Vinod K. Mony Shawna B. Benjamin Sisi Zhang Jason Locasale Gary J. Patti Nathan Lewis Eyleen J. O’Rourke Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion
description	The gut microbiota can alter the effects of anticancer fluoropyrimidines such as 5-fluorodeoxyuridine (FUdR) in the model organism C. elegans. Here, the authors show that these effects are further affected by diet, and dietary thymidine and serine increase FUdR toxicity in C. elegans via different mechanisms.
format	article
author	Wenfan Ke James A. Saba Cong-Hui Yao Michael A. Hilzendeger Anna Drangowska-Way Chintan Joshi Vinod K. Mony Shawna B. Benjamin Sisi Zhang Jason Locasale Gary J. Patti Nathan Lewis Eyleen J. O’Rourke
author_facet	Wenfan Ke James A. Saba Cong-Hui Yao Michael A. Hilzendeger Anna Drangowska-Way Chintan Joshi Vinod K. Mony Shawna B. Benjamin Sisi Zhang Jason Locasale Gary J. Patti Nathan Lewis Eyleen J. O’Rourke
author_sort	Wenfan Ke
title	Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion
title_short	Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion
title_full	Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion
title_fullStr	Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion
title_full_unstemmed	Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion
title_sort	dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/087ce5c3356748578c51b823b74c950a
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Dietary serine-microbiota interaction enhances chemotherapeutic toxicity without altering drug conversion

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