The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis

Alterations in the peripheral (e.g., serum, plasma, platelet) concentrations of arginine and its related catabolic products (i.e., ornithine, citrulline) in the urea and nitric oxide cycles have been reported to be associated with major depressive disorder (MDD). The meta-analysis herein aimed to ex...

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Autores principales:	Mingyue Fan, Xiao Gao, Li Li, Zhongyu Ren, Leanna M. W. Lui, Roger S. McIntyre, Kayla M. Teopiz, Peng Deng, Bing Cao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	arginine depression nitric oxide metabolism catabolism bipolar disorder Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/08833a2e4c994b1fa77de0760f3dfc96
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spelling	oai:doaj.org-article:08833a2e4c994b1fa77de0760f3dfc962021-11-18T06:18:52ZThe Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis1664-064010.3389/fpsyt.2021.686973https://doaj.org/article/08833a2e4c994b1fa77de0760f3dfc962021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.686973/fullhttps://doaj.org/toc/1664-0640Alterations in the peripheral (e.g., serum, plasma, platelet) concentrations of arginine and its related catabolic products (i.e., ornithine, citrulline) in the urea and nitric oxide cycles have been reported to be associated with major depressive disorder (MDD). The meta-analysis herein aimed to explore the association between the concentration of peripheral arginine, its catabolic products and MDD, as well as to discuss the possible role of arginine catabolism in the onset and progression of MDD. PubMed, EMBASE, PsycINFO and Web of Science were searched from inception to June 2020. The protocol for the meta-analysis herein has been registered at the Open Science Framework [https://doi.org/10.17605/osf.io/7fn59]. In total, 745 (47.5%) subjects with MDD and 823 (52.5%) healthy controls (HCs) from 13 articles with 16 studies were included. Fifteen of the included studies assessed concentrations of peripheral arginine, eight assessed concentrations of ornithine, and six assessed concentrations of citrulline. Results indicated that: (1) the concentrations of arginine, ornithine, and citrulline were not significantly different between individuals with MDD and HCs when serum, plasma and platelet are analyzed together, (2) in the subgroups of serum samples, the concentrations of arginine were lower in individuals with MDD than HCs, and (3) concurrent administration of psychotropic medications may be a confounding variable affecting the concentrations of arginine, ornithine, and citrulline. Our findings herein do not support the hypothesis that arginine catabolism between individuals with MDD and HCs are significantly different. The medication status and sample types should be considered as a key future research avenue for assessing arginine catabolism in MDD.Mingyue FanXiao GaoXiao GaoLi LiZhongyu RenLeanna M. W. LuiRoger S. McIntyreKayla M. TeopizPeng DengBing CaoBing CaoFrontiers Media S.A.articleargininedepressionnitric oxidemetabolismcatabolismbipolar disorderPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arginine depression nitric oxide metabolism catabolism bipolar disorder Psychiatry RC435-571
spellingShingle	arginine depression nitric oxide metabolism catabolism bipolar disorder Psychiatry RC435-571 Mingyue Fan Xiao Gao Xiao Gao Li Li Zhongyu Ren Leanna M. W. Lui Roger S. McIntyre Kayla M. Teopiz Peng Deng Bing Cao Bing Cao The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis
description	Alterations in the peripheral (e.g., serum, plasma, platelet) concentrations of arginine and its related catabolic products (i.e., ornithine, citrulline) in the urea and nitric oxide cycles have been reported to be associated with major depressive disorder (MDD). The meta-analysis herein aimed to explore the association between the concentration of peripheral arginine, its catabolic products and MDD, as well as to discuss the possible role of arginine catabolism in the onset and progression of MDD. PubMed, EMBASE, PsycINFO and Web of Science were searched from inception to June 2020. The protocol for the meta-analysis herein has been registered at the Open Science Framework [https://doi.org/10.17605/osf.io/7fn59]. In total, 745 (47.5%) subjects with MDD and 823 (52.5%) healthy controls (HCs) from 13 articles with 16 studies were included. Fifteen of the included studies assessed concentrations of peripheral arginine, eight assessed concentrations of ornithine, and six assessed concentrations of citrulline. Results indicated that: (1) the concentrations of arginine, ornithine, and citrulline were not significantly different between individuals with MDD and HCs when serum, plasma and platelet are analyzed together, (2) in the subgroups of serum samples, the concentrations of arginine were lower in individuals with MDD than HCs, and (3) concurrent administration of psychotropic medications may be a confounding variable affecting the concentrations of arginine, ornithine, and citrulline. Our findings herein do not support the hypothesis that arginine catabolism between individuals with MDD and HCs are significantly different. The medication status and sample types should be considered as a key future research avenue for assessing arginine catabolism in MDD.
format	article
author	Mingyue Fan Xiao Gao Xiao Gao Li Li Zhongyu Ren Leanna M. W. Lui Roger S. McIntyre Kayla M. Teopiz Peng Deng Bing Cao Bing Cao
author_facet	Mingyue Fan Xiao Gao Xiao Gao Li Li Zhongyu Ren Leanna M. W. Lui Roger S. McIntyre Kayla M. Teopiz Peng Deng Bing Cao Bing Cao
author_sort	Mingyue Fan
title	The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis
title_short	The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis
title_full	The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis
title_fullStr	The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis
title_full_unstemmed	The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis
title_sort	association between concentrations of arginine, ornithine, citrulline and major depressive disorder: a meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/08833a2e4c994b1fa77de0760f3dfc96
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The Association Between Concentrations of Arginine, Ornithine, Citrulline and Major Depressive Disorder: A Meta-Analysis

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