IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

Levels of IgM autoantibodies (AAbs) to native (double-stranded) and denaturated (single-stranded) DNA were studied in blood serum of sixty patients with hemorrhagic fever with renal syndrome (HFRS) and twenty-five healthy persons, using an ELISA technique. The median levels of IgM AAbs to double-str...

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Autores principales:	D. G. Ishmukhametova, B. K. Temesgen, O. V. Yakusheva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoimmunity anti-dna igm autoantibodies hemorrhagic fever renal syndrome Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/08889b88565c414ca3eae622ec45d2d8
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spelling	oai:doaj.org-article:08889b88565c414ca3eae622ec45d2d82021-11-18T08:03:38ZIgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME1563-06252313-741X10.15789/1563-0625-2010-4-5-375-380https://doaj.org/article/08889b88565c414ca3eae622ec45d2d82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/204https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XLevels of IgM autoantibodies (AAbs) to native (double-stranded) and denaturated (single-stranded) DNA were studied in blood serum of sixty patients with hemorrhagic fever with renal syndrome (HFRS) and twenty-five healthy persons, using an ELISA technique. The median levels of IgM AAbs to double-stranded DNA in blood serum of healthy persons and HFRS patients corresponded to 0.41 and 0.53 arbitrary units, respectively. Thus, the difference between the samples from HFRS and healthy persons proved to be non-significant. The median level of IgM AAbs to single-stranded DNA in blood sera of HFRS patients (0.71 arbitrary units) did significantly exceed serum values of healthy persons (0.57 arbitrary units). A probable involvement of IgM AAbs into regulation of IgG AAbs' production during virus-induced activation of autoimmune events in HFRS patients is discussed.D. G. IshmukhametovaB. K. TemesgenO. V. YakushevaSPb RAACIarticleautoimmunityanti-dna igm autoantibodieshemorrhagic feverrenal syndromeImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 4-5, Pp 375-380 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoimmunity anti-dna igm autoantibodies hemorrhagic fever renal syndrome Immunologic diseases. Allergy RC581-607
spellingShingle	autoimmunity anti-dna igm autoantibodies hemorrhagic fever renal syndrome Immunologic diseases. Allergy RC581-607 D. G. Ishmukhametova B. K. Temesgen O. V. Yakusheva IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
description	Levels of IgM autoantibodies (AAbs) to native (double-stranded) and denaturated (single-stranded) DNA were studied in blood serum of sixty patients with hemorrhagic fever with renal syndrome (HFRS) and twenty-five healthy persons, using an ELISA technique. The median levels of IgM AAbs to double-stranded DNA in blood serum of healthy persons and HFRS patients corresponded to 0.41 and 0.53 arbitrary units, respectively. Thus, the difference between the samples from HFRS and healthy persons proved to be non-significant. The median level of IgM AAbs to single-stranded DNA in blood sera of HFRS patients (0.71 arbitrary units) did significantly exceed serum values of healthy persons (0.57 arbitrary units). A probable involvement of IgM AAbs into regulation of IgG AAbs' production during virus-induced activation of autoimmune events in HFRS patients is discussed.
format	article
author	D. G. Ishmukhametova B. K. Temesgen O. V. Yakusheva
author_facet	D. G. Ishmukhametova B. K. Temesgen O. V. Yakusheva
author_sort	D. G. Ishmukhametova
title	IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_short	IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_full	IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_fullStr	IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_full_unstemmed	IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
title_sort	igm autoantibodies to dna in blood serum of the patients with hemorrhagic fever with renal syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/08889b88565c414ca3eae622ec45d2d8
work_keys_str_mv	AT dgishmukhametova igmautoantibodiestodnainbloodserumofthepatientswithhemorrhagicfeverwithrenalsyndrome AT bktemesgen igmautoantibodiestodnainbloodserumofthepatientswithhemorrhagicfeverwithrenalsyndrome AT ovyakusheva igmautoantibodiestodnainbloodserumofthepatientswithhemorrhagicfeverwithrenalsyndrome
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IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

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