Chiral acid-catalysed enantioselective C−H functionalization of toluene and its derivatives driven by visible light

Asymmetric transformations involving abundant chemical feedstocks such as toluene and its derivatives are rather rare. Here, the authors report the radical enantioselective C(sp3) −C(sp3) coupling of activated ketones with toluenes by means of chiral acid catalysis to afford enantioenriched tertiary...

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Autores principales: Fuyuan Li, Dong Tian, Yifan Fan, Richmond Lee, Gang Lu, Yanli Yin, Baokun Qiao, Xiaowei Zhao, Ziwei Xiao, Zhiyong Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0889e0279be74a959e50bb13a8b17b62
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Sumario:Asymmetric transformations involving abundant chemical feedstocks such as toluene and its derivatives are rather rare. Here, the authors report the radical enantioselective C(sp3) −C(sp3) coupling of activated ketones with toluenes by means of chiral acid catalysis to afford enantioenriched tertiary alcohols.