A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise

Abstract Exercise likely has numerous benefits for brain and cognition. However, those benefits and their causes remain imprecisely defined. If the brain does benefit from exercise it does so primarily through cumulative brief, “acute” exposures over a lifetime. The Dementia Risk and Dynamic Respons...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Dreu White, Casey S. John, Ashley Kucera, Bryce Truver, Rebecca J. Lepping, Paul J. Kueck, Phil Lee, Laura Martin, Sandra A. Billinger, Jeffrey M. Burns, Jill K. Morris, Eric D. Vidoni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/088de346d53049a4b24ab5be9b41efc6
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:088de346d53049a4b24ab5be9b41efc6
record_format dspace
spelling oai:doaj.org-article:088de346d53049a4b24ab5be9b41efc62021-12-02T17:40:49ZA methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise10.1038/s41598-021-92177-02045-2322https://doaj.org/article/088de346d53049a4b24ab5be9b41efc62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92177-0https://doaj.org/toc/2045-2322Abstract Exercise likely has numerous benefits for brain and cognition. However, those benefits and their causes remain imprecisely defined. If the brain does benefit from exercise it does so primarily through cumulative brief, “acute” exposures over a lifetime. The Dementia Risk and Dynamic Response to Exercise (DYNAMIC) clinical trial seeks to characterize the acute exercise response in cerebral perfusion, and circulating neurotrophic factors in older adults with and without the apolipoprotein e4 genotype (APOE4), the strongest genetic predictor of sporadic, late onset Alzheimer’s disease. DYNAMIC will enroll 60 older adults into a single moderate intensity bout of exercise intervention, measuring pre- and post-exercise cerebral blood flow (CBF) using arterial spin labeling, and neurotrophic factors. We expect that APOE4 carriers will have poor CBF regulation, i.e. slower return to baseline perfusion after exercise, and will demonstrate blunted neurotrophic response to exercise, with concentrations of neurotrophic factors positively correlating with CBF regulation. Preliminary findings on 7 older adults and 9 younger adults demonstrate that the experimental method can capture CBF and neurotrophic response over a time course. This methodology will provide important insight into acute exercise response and potential directions for clinical trial outcomes. ClinicalTrials.gov NCT04009629, Registered 05/07/2019.Dreu WhiteCasey S. JohnAshley KuceraBryce TruverRebecca J. LeppingPaul J. KueckPhil LeeLaura MartinSandra A. BillingerJeffrey M. BurnsJill K. MorrisEric D. VidoniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Dreu White
Casey S. John
Ashley Kucera
Bryce Truver
Rebecca J. Lepping
Paul J. Kueck
Phil Lee
Laura Martin
Sandra A. Billinger
Jeffrey M. Burns
Jill K. Morris
Eric D. Vidoni
A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise
description Abstract Exercise likely has numerous benefits for brain and cognition. However, those benefits and their causes remain imprecisely defined. If the brain does benefit from exercise it does so primarily through cumulative brief, “acute” exposures over a lifetime. The Dementia Risk and Dynamic Response to Exercise (DYNAMIC) clinical trial seeks to characterize the acute exercise response in cerebral perfusion, and circulating neurotrophic factors in older adults with and without the apolipoprotein e4 genotype (APOE4), the strongest genetic predictor of sporadic, late onset Alzheimer’s disease. DYNAMIC will enroll 60 older adults into a single moderate intensity bout of exercise intervention, measuring pre- and post-exercise cerebral blood flow (CBF) using arterial spin labeling, and neurotrophic factors. We expect that APOE4 carriers will have poor CBF regulation, i.e. slower return to baseline perfusion after exercise, and will demonstrate blunted neurotrophic response to exercise, with concentrations of neurotrophic factors positively correlating with CBF regulation. Preliminary findings on 7 older adults and 9 younger adults demonstrate that the experimental method can capture CBF and neurotrophic response over a time course. This methodology will provide important insight into acute exercise response and potential directions for clinical trial outcomes. ClinicalTrials.gov NCT04009629, Registered 05/07/2019.
format article
author Dreu White
Casey S. John
Ashley Kucera
Bryce Truver
Rebecca J. Lepping
Paul J. Kueck
Phil Lee
Laura Martin
Sandra A. Billinger
Jeffrey M. Burns
Jill K. Morris
Eric D. Vidoni
author_facet Dreu White
Casey S. John
Ashley Kucera
Bryce Truver
Rebecca J. Lepping
Paul J. Kueck
Phil Lee
Laura Martin
Sandra A. Billinger
Jeffrey M. Burns
Jill K. Morris
Eric D. Vidoni
author_sort Dreu White
title A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise
title_short A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise
title_full A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise
title_fullStr A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise
title_full_unstemmed A methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise
title_sort methodology for an acute exercise clinical trial called dementia risk and dynamic response to exercise
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/088de346d53049a4b24ab5be9b41efc6
work_keys_str_mv AT dreuwhite amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT caseysjohn amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT ashleykucera amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT brycetruver amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT rebeccajlepping amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT pauljkueck amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT phillee amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT lauramartin amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT sandraabillinger amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT jeffreymburns amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT jillkmorris amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT ericdvidoni amethodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT dreuwhite methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT caseysjohn methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT ashleykucera methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT brycetruver methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT rebeccajlepping methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT pauljkueck methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT phillee methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT lauramartin methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT sandraabillinger methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT jeffreymburns methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT jillkmorris methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
AT ericdvidoni methodologyforanacuteexerciseclinicaltrialcalleddementiariskanddynamicresponsetoexercise
_version_ 1718379687005126656