Effect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy

Meichen Qian,1 Na Wu,1,2 Ling Li,1 Wenshu Yu,1 Hong Ouyang,1 Xinyan Liu,1 Yujing He,1 Abdulrahman Al-Mureish2 1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of China; 2Clinical Skills Practice Teaching Center, Shengjing Hosp...

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Autores principales:	Qian M, Wu N, Li L, Yu W, Ouyang H, Liu X, He Y, Al-Mureish A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetic ketoacidosis gestational diabetes mellitus ketoacidosis pregestational diabetes mellitus. diabetes mellitus. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/088e6c7642c5417198463e93c2132a72
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spelling	oai:doaj.org-article:088e6c7642c5417198463e93c2132a722021-12-02T11:21:38ZEffect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy1178-7007https://doaj.org/article/088e6c7642c5417198463e93c2132a722020-11-01T00:00:00Zhttps://www.dovepress.com/effect-of-elevated-ketone-body-on-maternal-and-infant-outcome-of-pregn-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Meichen Qian,1 Na Wu,1,2 Ling Li,1 Wenshu Yu,1 Hong Ouyang,1 Xinyan Liu,1 Yujing He,1 Abdulrahman Al-Mureish2 1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of China; 2Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of ChinaCorrespondence: Na WuDepartment of Endocrinology, Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of ChinaEmail 3441535223@qq.comAbstract: Ketone bodies are one of the products of fat metabolism which can be used as an alternative energy source for the human body in states of glucose deficiency. Normal pregnant women may develop ketosis due to physiological changes during pregnancy, while pregnant women with abnormal glucose metabolism are more likely to develop ketosis due to abnormal insulin secretion. Animal experiments and clinical studies have shown that exposure to high-ketone environments during pregnancy is closely related to adverse maternal and infant outcomes. However, there is no unified conclusion on whether ketone bodies should be routinely monitored during pregnancy. This review summarizes the existing studies on ketone body levels and pregnancy outcomes in the case of abnormal blood glucose during pregnancy, elaborates the current guidelines on the level of ketone bodies, provides the detection and treatment of ketosis in pregnant women with abnormal blood glucose in the clinical practice.Keywords: diabetic ketoacidosis, gestational diabetes mellitus, ketoacidosis, pregestational diabetes mellitus, diabetes mellitusQian MWu NLi LYu WOuyang HLiu XHe YAl-Mureish ADove Medical Pressarticlediabetic ketoacidosisgestational diabetes mellitusketoacidosispregestational diabetes mellitus. diabetes mellitus.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 4581-4588 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic ketoacidosis gestational diabetes mellitus ketoacidosis pregestational diabetes mellitus. diabetes mellitus. Specialties of internal medicine RC581-951
spellingShingle	diabetic ketoacidosis gestational diabetes mellitus ketoacidosis pregestational diabetes mellitus. diabetes mellitus. Specialties of internal medicine RC581-951 Qian M Wu N Li L Yu W Ouyang H Liu X He Y Al-Mureish A Effect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy
description	Meichen Qian,1 Na Wu,1,2 Ling Li,1 Wenshu Yu,1 Hong Ouyang,1 Xinyan Liu,1 Yujing He,1 Abdulrahman Al-Mureish2 1Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of China; 2Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of ChinaCorrespondence: Na WuDepartment of Endocrinology, Clinical Skills Practice Teaching Center, Shengjing Hospital of China Medical University, Shenyang 110004, People’s Republic of ChinaEmail 3441535223@qq.comAbstract: Ketone bodies are one of the products of fat metabolism which can be used as an alternative energy source for the human body in states of glucose deficiency. Normal pregnant women may develop ketosis due to physiological changes during pregnancy, while pregnant women with abnormal glucose metabolism are more likely to develop ketosis due to abnormal insulin secretion. Animal experiments and clinical studies have shown that exposure to high-ketone environments during pregnancy is closely related to adverse maternal and infant outcomes. However, there is no unified conclusion on whether ketone bodies should be routinely monitored during pregnancy. This review summarizes the existing studies on ketone body levels and pregnancy outcomes in the case of abnormal blood glucose during pregnancy, elaborates the current guidelines on the level of ketone bodies, provides the detection and treatment of ketosis in pregnant women with abnormal blood glucose in the clinical practice.Keywords: diabetic ketoacidosis, gestational diabetes mellitus, ketoacidosis, pregestational diabetes mellitus, diabetes mellitus
format	article
author	Qian M Wu N Li L Yu W Ouyang H Liu X He Y Al-Mureish A
author_facet	Qian M Wu N Li L Yu W Ouyang H Liu X He Y Al-Mureish A
author_sort	Qian M
title	Effect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy
title_short	Effect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy
title_full	Effect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy
title_fullStr	Effect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy
title_full_unstemmed	Effect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy
title_sort	effect of elevated ketone body on maternal and infant outcome of pregnant women with abnormal glucose metabolism during pregnancy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/088e6c7642c5417198463e93c2132a72
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Effect of Elevated Ketone Body on Maternal and Infant Outcome of Pregnant Women with Abnormal Glucose Metabolism During Pregnancy

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