Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Mutations of Neuroligin 3 (NLGN3) have been associated with autism spectrum disorder (ASD). Here, the authors identify a previously undescribed interaction between NLGN3 and a splice variant of protein tyrosine phosphatase δ (PTP δ) and its role in development of social behaviour in mice.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/088ec8c07114426fb988df9303a95e47 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:088ec8c07114426fb988df9303a95e47 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:088ec8c07114426fb988df9303a95e472021-12-02T13:24:22ZCanonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice10.1038/s41467-021-22059-62041-1723https://doaj.org/article/088ec8c07114426fb988df9303a95e472021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22059-6https://doaj.org/toc/2041-1723Mutations of Neuroligin 3 (NLGN3) have been associated with autism spectrum disorder (ASD). Here, the authors identify a previously undescribed interaction between NLGN3 and a splice variant of protein tyrosine phosphatase δ (PTP δ) and its role in development of social behaviour in mice.Tomoyuki YoshidaAtsushi YamagataAyako ImaiJuhyon KimHironori IzumiShogo NakashimaTomoko ShiroshimaAsami MaedaShiho Iwasawa-OkamotoKenji AzechiFumina OsakaTakashi SaitohKatsumi MaenakaTakashi ShimadaYuko FukataMasaki FukataJumpei MatsumotoHisao NishijoKeizo TakaoShinji TanakaShigeo OkabeKatsuhiko TabuchiTakeshi UemuraMasayoshi MishinaHisashi MoriShuya FukaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tomoyuki Yoshida Atsushi Yamagata Ayako Imai Juhyon Kim Hironori Izumi Shogo Nakashima Tomoko Shiroshima Asami Maeda Shiho Iwasawa-Okamoto Kenji Azechi Fumina Osaka Takashi Saitoh Katsumi Maenaka Takashi Shimada Yuko Fukata Masaki Fukata Jumpei Matsumoto Hisao Nishijo Keizo Takao Shinji Tanaka Shigeo Okabe Katsuhiko Tabuchi Takeshi Uemura Masayoshi Mishina Hisashi Mori Shuya Fukai Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice |
| description |
Mutations of Neuroligin 3 (NLGN3) have been associated with autism spectrum disorder (ASD). Here, the authors identify a previously undescribed interaction between NLGN3 and a splice variant of protein tyrosine phosphatase δ (PTP δ) and its role in development of social behaviour in mice. |
| format |
article |
| author |
Tomoyuki Yoshida Atsushi Yamagata Ayako Imai Juhyon Kim Hironori Izumi Shogo Nakashima Tomoko Shiroshima Asami Maeda Shiho Iwasawa-Okamoto Kenji Azechi Fumina Osaka Takashi Saitoh Katsumi Maenaka Takashi Shimada Yuko Fukata Masaki Fukata Jumpei Matsumoto Hisao Nishijo Keizo Takao Shinji Tanaka Shigeo Okabe Katsuhiko Tabuchi Takeshi Uemura Masayoshi Mishina Hisashi Mori Shuya Fukai |
| author_facet |
Tomoyuki Yoshida Atsushi Yamagata Ayako Imai Juhyon Kim Hironori Izumi Shogo Nakashima Tomoko Shiroshima Asami Maeda Shiho Iwasawa-Okamoto Kenji Azechi Fumina Osaka Takashi Saitoh Katsumi Maenaka Takashi Shimada Yuko Fukata Masaki Fukata Jumpei Matsumoto Hisao Nishijo Keizo Takao Shinji Tanaka Shigeo Okabe Katsuhiko Tabuchi Takeshi Uemura Masayoshi Mishina Hisashi Mori Shuya Fukai |
| author_sort |
Tomoyuki Yoshida |
| title |
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice |
| title_short |
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice |
| title_full |
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice |
| title_fullStr |
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice |
| title_full_unstemmed |
Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice |
| title_sort |
canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/088ec8c07114426fb988df9303a95e47 |
| work_keys_str_mv |
AT tomoyukiyoshida canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT atsushiyamagata canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT ayakoimai canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT juhyonkim canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT hironoriizumi canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT shogonakashima canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT tomokoshiroshima canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT asamimaeda canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT shihoiwasawaokamoto canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT kenjiazechi canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT fuminaosaka canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT takashisaitoh canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT katsumimaenaka canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT takashishimada canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT yukofukata canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT masakifukata canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT jumpeimatsumoto canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT hisaonishijo canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT keizotakao canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT shinjitanaka canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT shigeookabe canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT katsuhikotabuchi canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT takeshiuemura canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT masayoshimishina canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT hisashimori canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice AT shuyafukai canonicalversusnoncanonicaltranssynapticsignalingofneuroligin3tunesdevelopmentofsocialityinmice |
| _version_ |
1718393073021485056 |