Synthesis of difluoromethylated allenes through trifunctionalization of 1,3-enynes

Fluorinated or fluoroalkylated allenes are versatile building blocks for medicinal and material chemistry. Here, the authors show a regioselective trifunctionalization of 1,3-enynes proceeding through double C-F bond formation and concomitant installation of a -NSO2Ph group to the allene moiety.

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Autores principales: Munira Taj Muhammad, Yihang Jiao, Changqing Ye, Mong-Feng Chiou, Muhammad Israr, Xiaotao Zhu, Yajun Li, Zhenhai Wen, Armido Studer, Hongli Bao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/088ff620e653493a9b6d0f5ab973aca1
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Sumario:Fluorinated or fluoroalkylated allenes are versatile building blocks for medicinal and material chemistry. Here, the authors show a regioselective trifunctionalization of 1,3-enynes proceeding through double C-F bond formation and concomitant installation of a -NSO2Ph group to the allene moiety.