Metabolomic differences between critically Ill women and men

Abstract Metabolism differs in women and men at homeostasis. Critically ill patients have profound dysregulation of homeostasis and metabolism. It is not clear if the metabolic response to critical illness differs in women compared to men. Such sex-specific differences in illness response would have...

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Autores principales:	Sowmya Chary, Karin Amrein, Jessica A. Lasky-Su, Harald Dobnig, Kenneth B. Christopher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08901062dd8d4176b2c1e7b834afaf46
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spelling	oai:doaj.org-article:08901062dd8d4176b2c1e7b834afaf462021-12-02T10:54:14ZMetabolomic differences between critically Ill women and men10.1038/s41598-021-83602-52045-2322https://doaj.org/article/08901062dd8d4176b2c1e7b834afaf462021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83602-5https://doaj.org/toc/2045-2322Abstract Metabolism differs in women and men at homeostasis. Critically ill patients have profound dysregulation of homeostasis and metabolism. It is not clear if the metabolic response to critical illness differs in women compared to men. Such sex-specific differences in illness response would have consequences for personalized medicine. Our aim was to determine the sex-specific metabolomic response to early critical illness. We performed a post-hoc metabolomics study of the VITdAL-ICU trial where subjects received high dose vitamin D3 or placebo. Using mixed-effects modeling, we studied sex-specific changes in metabolites over time adjusted for age, Simplified Acute Physiology Score II, admission diagnosis, day 0 25-hydroxyvitamin D level, and 25-hydroxyvitamin D response to intervention. In women, multiple members of the sphingomyelin and lysophospholipid metabolite classes had significantly positive Bonferroni corrected associations over time compared to men. Further, multiple representatives of the acylcarnitine, androgenic steroid, bile acid, nucleotide and amino acid metabolite classes had significantly negative Bonferroni corrected associations over time compared to men. Gaussian graphical model analyses revealed sex-specific functional modules. Our findings show that robust and coordinated sex-specific metabolite differences exist early in critical illness.Sowmya CharyKarin AmreinJessica A. Lasky-SuHarald DobnigKenneth B. ChristopherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sowmya Chary Karin Amrein Jessica A. Lasky-Su Harald Dobnig Kenneth B. Christopher Metabolomic differences between critically Ill women and men
description	Abstract Metabolism differs in women and men at homeostasis. Critically ill patients have profound dysregulation of homeostasis and metabolism. It is not clear if the metabolic response to critical illness differs in women compared to men. Such sex-specific differences in illness response would have consequences for personalized medicine. Our aim was to determine the sex-specific metabolomic response to early critical illness. We performed a post-hoc metabolomics study of the VITdAL-ICU trial where subjects received high dose vitamin D3 or placebo. Using mixed-effects modeling, we studied sex-specific changes in metabolites over time adjusted for age, Simplified Acute Physiology Score II, admission diagnosis, day 0 25-hydroxyvitamin D level, and 25-hydroxyvitamin D response to intervention. In women, multiple members of the sphingomyelin and lysophospholipid metabolite classes had significantly positive Bonferroni corrected associations over time compared to men. Further, multiple representatives of the acylcarnitine, androgenic steroid, bile acid, nucleotide and amino acid metabolite classes had significantly negative Bonferroni corrected associations over time compared to men. Gaussian graphical model analyses revealed sex-specific functional modules. Our findings show that robust and coordinated sex-specific metabolite differences exist early in critical illness.
format	article
author	Sowmya Chary Karin Amrein Jessica A. Lasky-Su Harald Dobnig Kenneth B. Christopher
author_facet	Sowmya Chary Karin Amrein Jessica A. Lasky-Su Harald Dobnig Kenneth B. Christopher
author_sort	Sowmya Chary
title	Metabolomic differences between critically Ill women and men
title_short	Metabolomic differences between critically Ill women and men
title_full	Metabolomic differences between critically Ill women and men
title_fullStr	Metabolomic differences between critically Ill women and men
title_full_unstemmed	Metabolomic differences between critically Ill women and men
title_sort	metabolomic differences between critically ill women and men
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/08901062dd8d4176b2c1e7b834afaf46
work_keys_str_mv	AT sowmyachary metabolomicdifferencesbetweencriticallyillwomenandmen AT karinamrein metabolomicdifferencesbetweencriticallyillwomenandmen AT jessicaalaskysu metabolomicdifferencesbetweencriticallyillwomenandmen AT haralddobnig metabolomicdifferencesbetweencriticallyillwomenandmen AT kennethbchristopher metabolomicdifferencesbetweencriticallyillwomenandmen
_version_	1718396451022700544

Metabolomic differences between critically Ill women and men

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