HEB is required for the specification of fetal IL-17-producing γδ T cells
The γδ T cell pool includes abundant IL-17-producing cells that protect mucosal surfaces, but the signals that control γδ T cell specification are unclear. Here the authors identify a role for the transcription factor HEB, and antagonistic activity of Id3, in the development of these cells.
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Nature Portfolio
2017
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oai:doaj.org-article:0891f0415e62442cafff5d926ff15f1e2021-12-02T14:42:55ZHEB is required for the specification of fetal IL-17-producing γδ T cells10.1038/s41467-017-02225-52041-1723https://doaj.org/article/0891f0415e62442cafff5d926ff15f1e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02225-5https://doaj.org/toc/2041-1723The γδ T cell pool includes abundant IL-17-producing cells that protect mucosal surfaces, but the signals that control γδ T cell specification are unclear. Here the authors identify a role for the transcription factor HEB, and antagonistic activity of Id3, in the development of these cells.Tracy S. H. InAshton Trotman-GrantShawn FahlEdward L. Y. ChenPayam ZarinAmanda J. MooreDavid L. WiestJuan Carlos Zúñiga-PflückerMichele K. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tracy S. H. In Ashton Trotman-Grant Shawn Fahl Edward L. Y. Chen Payam Zarin Amanda J. Moore David L. Wiest Juan Carlos Zúñiga-Pflücker Michele K. Anderson HEB is required for the specification of fetal IL-17-producing γδ T cells |
| description |
The γδ T cell pool includes abundant IL-17-producing cells that protect mucosal surfaces, but the signals that control γδ T cell specification are unclear. Here the authors identify a role for the transcription factor HEB, and antagonistic activity of Id3, in the development of these cells. |
| format |
article |
| author |
Tracy S. H. In Ashton Trotman-Grant Shawn Fahl Edward L. Y. Chen Payam Zarin Amanda J. Moore David L. Wiest Juan Carlos Zúñiga-Pflücker Michele K. Anderson |
| author_facet |
Tracy S. H. In Ashton Trotman-Grant Shawn Fahl Edward L. Y. Chen Payam Zarin Amanda J. Moore David L. Wiest Juan Carlos Zúñiga-Pflücker Michele K. Anderson |
| author_sort |
Tracy S. H. In |
| title |
HEB is required for the specification of fetal IL-17-producing γδ T cells |
| title_short |
HEB is required for the specification of fetal IL-17-producing γδ T cells |
| title_full |
HEB is required for the specification of fetal IL-17-producing γδ T cells |
| title_fullStr |
HEB is required for the specification of fetal IL-17-producing γδ T cells |
| title_full_unstemmed |
HEB is required for the specification of fetal IL-17-producing γδ T cells |
| title_sort |
heb is required for the specification of fetal il-17-producing γδ t cells |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0891f0415e62442cafff5d926ff15f1e |
| work_keys_str_mv |
AT tracyshin hebisrequiredforthespecificationoffetalil17producinggdtcells AT ashtontrotmangrant hebisrequiredforthespecificationoffetalil17producinggdtcells AT shawnfahl hebisrequiredforthespecificationoffetalil17producinggdtcells AT edwardlychen hebisrequiredforthespecificationoffetalil17producinggdtcells AT payamzarin hebisrequiredforthespecificationoffetalil17producinggdtcells AT amandajmoore hebisrequiredforthespecificationoffetalil17producinggdtcells AT davidlwiest hebisrequiredforthespecificationoffetalil17producinggdtcells AT juancarloszunigapflucker hebisrequiredforthespecificationoffetalil17producinggdtcells AT michelekanderson hebisrequiredforthespecificationoffetalil17producinggdtcells |
| _version_ |
1718389549761036288 |