Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study

Benping Zhang,1,* Chen Dong,2,* Shengzhong Li,3 Xiaoqing Song,1 Wang Wei,4 Li Liu1 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 2Department of Pediatrics, Tongji Hospit...

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Autores principales:	Zhang B, Dong C, Li S, Song X, Wei W, Liu L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	tg/hdl-c insulin resistance myocardial injury heart failure mortality covid-19 Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0893c30a4aa14595a09935ff1098f839
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spelling	oai:doaj.org-article:0893c30a4aa14595a09935ff1098f8392021-12-02T10:29:37ZTriglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study1178-7007https://doaj.org/article/0893c30a4aa14595a09935ff1098f8392020-10-01T00:00:00Zhttps://www.dovepress.com/triglyceride-to-high-density-lipoprotein-cholesterol-ratio-is-an-impor-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Benping Zhang,1,* Chen Dong,2,* Shengzhong Li,3 Xiaoqing Song,1 Wang Wei,4 Li Liu1 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 2Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 3Department of Surgery, Wuhan Jinyintan Hospital, Wuhan, Hubei 430023, People’s Republic of China; 4Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li LiuDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, Hubei 430030, People’s Republic of ChinaTel +86-027-83663470Fax +86-027-83662883Email liliu@tjh.tjmu.edu.cnBackground: Acute myocardial injury and heart failure characterized by elevated cardiac troponin and decreased heart pump function are significant clinical features and prognostic factors of coronavirus disease-19 (COVID-19). Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an indicator of insulin resistance. This study aimed to explore the association of the TG/HDL-C ratio with cardiovascular risk and prognosis in COVID-19.Methods: Ninety-eight laboratory-confirmed patients with COVID-19 admitted in a tertiary teaching hospital in Wuhan, China, were enrolled in this retrospective study. Regression models were used to investigate the association between TG/HDL-C ratio with myocardial injury, heart failure, severity, and mortality in COVID-19.Results: Among the 98 patients, the mean age was 63.9± 1.4 years, and male sex (58, 59%) was predominant. Forty-six patients (47%) were admitted to the intensive care unit (ICU), 32 (33%) and 46 (47%) patients suffered from myocardial injury and heart failure, respectively, and 36 (37%) patients died. The TG/HDL-C ratio was increased in patients with myocardial injury, heart failure, severe illness, and fatal outcome (P< 0.05 for each). Baseline TG/HDL-C ratio significantly correlated with log transformed levels of plasma high-sensitivity cardiac troponin I (r=0.251, P=0.018), N-terminal brain natriuretic propeptide (r=0.274, P=0.008), glycated hemoglobin (r=0.239, P=0.038), and interleukin-6 (r=0.218, P=0.042). Multivariate logistic regression analysis showed that an increased TG/HDL-C ratio was independently associated with the risk of myocardial injury [odds ratio (OR)=2.73; P=0.013], heart failure (OR=2.64; P=0.019), disease severity (OR=3.01; P=0.032), and fatal outcome (OR=2.97; P=0.014).Conclusion: Increased TG/HDL-C ratio was independently associated with myocardial injury, heart failure, disease severity, and mortality in patients with COVID-19, and it may be a useful marker for early identification of patients with high risk and poor outcome.Keywords: TG/HDL-C, insulin resistance, myocardial injury, heart failure, mortality, COVID-19Zhang BDong CLi SSong XWei WLiu LDove Medical Pressarticletg/hdl-cinsulin resistancemyocardial injuryheart failuremortalitycovid-19Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3925-3936 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	tg/hdl-c insulin resistance myocardial injury heart failure mortality covid-19 Specialties of internal medicine RC581-951
spellingShingle	tg/hdl-c insulin resistance myocardial injury heart failure mortality covid-19 Specialties of internal medicine RC581-951 Zhang B Dong C Li S Song X Wei W Liu L Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study
description	Benping Zhang,1,* Chen Dong,2,* Shengzhong Li,3 Xiaoqing Song,1 Wang Wei,4 Li Liu1 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 2Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China; 3Department of Surgery, Wuhan Jinyintan Hospital, Wuhan, Hubei 430023, People’s Republic of China; 4Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li LiuDepartment of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, Hubei 430030, People’s Republic of ChinaTel +86-027-83663470Fax +86-027-83662883Email liliu@tjh.tjmu.edu.cnBackground: Acute myocardial injury and heart failure characterized by elevated cardiac troponin and decreased heart pump function are significant clinical features and prognostic factors of coronavirus disease-19 (COVID-19). Triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio is an indicator of insulin resistance. This study aimed to explore the association of the TG/HDL-C ratio with cardiovascular risk and prognosis in COVID-19.Methods: Ninety-eight laboratory-confirmed patients with COVID-19 admitted in a tertiary teaching hospital in Wuhan, China, were enrolled in this retrospective study. Regression models were used to investigate the association between TG/HDL-C ratio with myocardial injury, heart failure, severity, and mortality in COVID-19.Results: Among the 98 patients, the mean age was 63.9± 1.4 years, and male sex (58, 59%) was predominant. Forty-six patients (47%) were admitted to the intensive care unit (ICU), 32 (33%) and 46 (47%) patients suffered from myocardial injury and heart failure, respectively, and 36 (37%) patients died. The TG/HDL-C ratio was increased in patients with myocardial injury, heart failure, severe illness, and fatal outcome (P< 0.05 for each). Baseline TG/HDL-C ratio significantly correlated with log transformed levels of plasma high-sensitivity cardiac troponin I (r=0.251, P=0.018), N-terminal brain natriuretic propeptide (r=0.274, P=0.008), glycated hemoglobin (r=0.239, P=0.038), and interleukin-6 (r=0.218, P=0.042). Multivariate logistic regression analysis showed that an increased TG/HDL-C ratio was independently associated with the risk of myocardial injury [odds ratio (OR)=2.73; P=0.013], heart failure (OR=2.64; P=0.019), disease severity (OR=3.01; P=0.032), and fatal outcome (OR=2.97; P=0.014).Conclusion: Increased TG/HDL-C ratio was independently associated with myocardial injury, heart failure, disease severity, and mortality in patients with COVID-19, and it may be a useful marker for early identification of patients with high risk and poor outcome.Keywords: TG/HDL-C, insulin resistance, myocardial injury, heart failure, mortality, COVID-19
format	article
author	Zhang B Dong C Li S Song X Wei W Liu L
author_facet	Zhang B Dong C Li S Song X Wei W Liu L
author_sort	Zhang B
title	Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study
title_short	Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study
title_full	Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study
title_fullStr	Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study
title_full_unstemmed	Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study
title_sort	triglyceride to high-density lipoprotein cholesterol ratio is an important determinant of cardiovascular risk and poor prognosis in coronavirus disease-19: a retrospective case series study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0893c30a4aa14595a09935ff1098f839
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Triglyceride to High-Density Lipoprotein Cholesterol Ratio is an Important Determinant of Cardiovascular Risk and Poor Prognosis in Coronavirus Disease-19: A Retrospective Case Series Study

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