NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

A gene regulatory network, including the transcription factor Nkx2-5, regulates cardiac development. Here, the authors show that on deletion of NKX2-5 from human embryonic stem cells, there is impaired cardiomyogenesis and changes in action potentials, and that this is regulated via HEY2.

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Autores principales:	David J. Anderson, David I. Kaplan, Katrina M. Bell, Katerina Koutsis, John M. Haynes, Richard J. Mills, Dean G. Phelan, Elizabeth L. Qian, Ana Rita Leitoguinho, Deevina Arasaratnam, Tanya Labonne, Elizabeth S. Ng, Richard P. Davis, Simona Casini, Robert Passier, James E. Hudson, Enzo R. Porrello, Mauro W. Costa, Arash Rafii, Clare L. Curl, Lea M. Delbridge, Richard P. Harvey, Alicia Oshlack, Michael M. Cheung, Christine L. Mummery, Stephen Petrou, Andrew G. Elefanty, Edouard G. Stanley, David A. Elliott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0896462d0f5d479da41ae7191f638c59
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spelling	oai:doaj.org-article:0896462d0f5d479da41ae7191f638c592021-12-02T15:34:23ZNKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network10.1038/s41467-018-03714-x2041-1723https://doaj.org/article/0896462d0f5d479da41ae7191f638c592018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03714-xhttps://doaj.org/toc/2041-1723A gene regulatory network, including the transcription factor Nkx2-5, regulates cardiac development. Here, the authors show that on deletion of NKX2-5 from human embryonic stem cells, there is impaired cardiomyogenesis and changes in action potentials, and that this is regulated via HEY2.David J. AndersonDavid I. KaplanKatrina M. BellKaterina KoutsisJohn M. HaynesRichard J. MillsDean G. PhelanElizabeth L. QianAna Rita LeitoguinhoDeevina ArasaratnamTanya LabonneElizabeth S. NgRichard P. DavisSimona CasiniRobert PassierJames E. HudsonEnzo R. PorrelloMauro W. CostaArash RafiiClare L. CurlLea M. DelbridgeRichard P. HarveyAlicia OshlackMichael M. CheungChristine L. MummeryStephen PetrouAndrew G. ElefantyEdouard G. StanleyDavid A. ElliottNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David J. Anderson David I. Kaplan Katrina M. Bell Katerina Koutsis John M. Haynes Richard J. Mills Dean G. Phelan Elizabeth L. Qian Ana Rita Leitoguinho Deevina Arasaratnam Tanya Labonne Elizabeth S. Ng Richard P. Davis Simona Casini Robert Passier James E. Hudson Enzo R. Porrello Mauro W. Costa Arash Rafii Clare L. Curl Lea M. Delbridge Richard P. Harvey Alicia Oshlack Michael M. Cheung Christine L. Mummery Stephen Petrou Andrew G. Elefanty Edouard G. Stanley David A. Elliott NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
description	A gene regulatory network, including the transcription factor Nkx2-5, regulates cardiac development. Here, the authors show that on deletion of NKX2-5 from human embryonic stem cells, there is impaired cardiomyogenesis and changes in action potentials, and that this is regulated via HEY2.
format	article
author	David J. Anderson David I. Kaplan Katrina M. Bell Katerina Koutsis John M. Haynes Richard J. Mills Dean G. Phelan Elizabeth L. Qian Ana Rita Leitoguinho Deevina Arasaratnam Tanya Labonne Elizabeth S. Ng Richard P. Davis Simona Casini Robert Passier James E. Hudson Enzo R. Porrello Mauro W. Costa Arash Rafii Clare L. Curl Lea M. Delbridge Richard P. Harvey Alicia Oshlack Michael M. Cheung Christine L. Mummery Stephen Petrou Andrew G. Elefanty Edouard G. Stanley David A. Elliott
author_facet	David J. Anderson David I. Kaplan Katrina M. Bell Katerina Koutsis John M. Haynes Richard J. Mills Dean G. Phelan Elizabeth L. Qian Ana Rita Leitoguinho Deevina Arasaratnam Tanya Labonne Elizabeth S. Ng Richard P. Davis Simona Casini Robert Passier James E. Hudson Enzo R. Porrello Mauro W. Costa Arash Rafii Clare L. Curl Lea M. Delbridge Richard P. Harvey Alicia Oshlack Michael M. Cheung Christine L. Mummery Stephen Petrou Andrew G. Elefanty Edouard G. Stanley David A. Elliott
author_sort	David J. Anderson
title	NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
title_short	NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
title_full	NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
title_fullStr	NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
title_full_unstemmed	NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network
title_sort	nkx2-5 regulates human cardiomyogenesis via a hey2 dependent transcriptional network
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0896462d0f5d479da41ae7191f638c59
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NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

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