Molecular Basis for <named-content content-type="genus-species">Bordetella pertussis</named-content> Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex

Molecular Basis for <named-content content-type="genus-species">Bordetella pertussis</named-content> Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex

ABSTRACT Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, a C1 inhibitor (C1-INH), is a key regulator (inhibitor) of serine proteases of all the above-mentioned pathways. Recently, an au...

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Autores principales: Arun Dhillon, Justin C. Deme, Emily Furlong, Dorina Roem, Ilse Jongerius, Steven Johnson, Susan M. Lea
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
Bordetella pertussis
immune evasion
complement system
serpin
autotransporters
C1-INH
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/089a29c6c6894167ac20a9fe9aa84830
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