Frailty in Older Patients with Acute Coronary Syndrome in Vietnam

Tan Van Nguyen,1,2 Duong Le,1,2 Khuong Dang Tran,1 Khai Xuan Bui,1 Tu Ngoc Nguyen3 1Department of Geriatrics & Gerontology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; 2Department of Interventional Cardiology, Thong Nhat Hospital, Ho Chi Minh City, Vietnam; 3Westmead Appl...

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Autores principales:	Nguyen TV, Le D, Tran KD, Bui KX, Nguyen TN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	frailty acute coronary syndrome cardiovascular disease vietnam Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/089da7f1a5b640638db6e0ff300c1755
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spelling	oai:doaj.org-article:089da7f1a5b640638db6e0ff300c17552021-12-02T10:06:18ZFrailty in Older Patients with Acute Coronary Syndrome in Vietnam1178-1998https://doaj.org/article/089da7f1a5b640638db6e0ff300c17552019-12-01T00:00:00Zhttps://www.dovepress.com/frailty-in-older-patients-with-acute-coronary-syndrome-in-vietnam-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Tan Van Nguyen,1,2 Duong Le,1,2 Khuong Dang Tran,1 Khai Xuan Bui,1 Tu Ngoc Nguyen3 1Department of Geriatrics & Gerontology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; 2Department of Interventional Cardiology, Thong Nhat Hospital, Ho Chi Minh City, Vietnam; 3Westmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaCorrespondence: Tan Van NguyenDepartment of Geriatrics & Gerontology, University of Medicine and Pharmacy, Ho Chi Minh City, VietnamTel +84 903 739 273Email nguyenvtan10@ump.edu.vnBackground: There has been limited evidence about frailty in older patients with acute coronary syndrome (ACS) in Vietnam.Aim: (1) To investigate the prevalence of frailty in older patients hospitalised with ACS and its associated factors; (2) To investigate the impact of frailty on percutaneous coronary intervention (PCI) and adverse outcomes in this population.Methods: Patients aged ≥60 with ACS admitted to two teaching hospitals in Vietnam were recruited from 9/2017 to 4/2018. Frailty was defined by the Reported Edmonton Frail Scale. Multivariate logistic regression was applied to investigate the associated factors of frailty and the impact of frailty on PCI and adverse outcomes.Results: There were 324 participants, mean age 73.5±8.3, 39.2% female. The prevalence of frailty was 48.1%. Advanced age, female gender, history of hypertension, heart failure, stroke and chronic kidney disease were significantly associated with a frailty status. Overall, 50.3% of the participants received PCI (58.3% in the non-frail vs 41.7% in the frail, p=0.003). However, frailty did not have an independent impact on PCI (adjusted OR 0.66, 95% CI 0.41–1.08). Frailty was significantly associated with increased risk of having arrhythmia during hospitalisation (adjusted OR 2.24, 95% CI 1.32–3.80), hospital-acquired pneumonia (adjusted OR 2.27, 95% CI 1.24–4.17), in-hospital mortality (adjusted OR 3.02, 95% CI 1.35–6.75), 30-day mortality (adjusted OR 3.28, 95% CI 1.59–6.76), and 30-day readmission (adjusted OR 2.53, 95% CI 1.38–4.63).Conclusion: In this study, frailty was present in nearly half of older patients with ACS and was associated with increased adverse outcomes. These findings suggest that frailty screening should be performed in older patients with ACS in Vietnam.Keywords: frailty, acute coronary syndrome, elderly, older patients, adverse outcomes, VietnamNguyen TVLe DTran KDBui KXNguyen TNDove Medical Pressarticlefrailtyacute coronary syndromecardiovascular diseasevietnamGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 2213-2222 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	frailty acute coronary syndrome cardiovascular disease vietnam Geriatrics RC952-954.6
spellingShingle	frailty acute coronary syndrome cardiovascular disease vietnam Geriatrics RC952-954.6 Nguyen TV Le D Tran KD Bui KX Nguyen TN Frailty in Older Patients with Acute Coronary Syndrome in Vietnam
description	Tan Van Nguyen,1,2 Duong Le,1,2 Khuong Dang Tran,1 Khai Xuan Bui,1 Tu Ngoc Nguyen3 1Department of Geriatrics & Gerontology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; 2Department of Interventional Cardiology, Thong Nhat Hospital, Ho Chi Minh City, Vietnam; 3Westmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, AustraliaCorrespondence: Tan Van NguyenDepartment of Geriatrics & Gerontology, University of Medicine and Pharmacy, Ho Chi Minh City, VietnamTel +84 903 739 273Email nguyenvtan10@ump.edu.vnBackground: There has been limited evidence about frailty in older patients with acute coronary syndrome (ACS) in Vietnam.Aim: (1) To investigate the prevalence of frailty in older patients hospitalised with ACS and its associated factors; (2) To investigate the impact of frailty on percutaneous coronary intervention (PCI) and adverse outcomes in this population.Methods: Patients aged ≥60 with ACS admitted to two teaching hospitals in Vietnam were recruited from 9/2017 to 4/2018. Frailty was defined by the Reported Edmonton Frail Scale. Multivariate logistic regression was applied to investigate the associated factors of frailty and the impact of frailty on PCI and adverse outcomes.Results: There were 324 participants, mean age 73.5±8.3, 39.2% female. The prevalence of frailty was 48.1%. Advanced age, female gender, history of hypertension, heart failure, stroke and chronic kidney disease were significantly associated with a frailty status. Overall, 50.3% of the participants received PCI (58.3% in the non-frail vs 41.7% in the frail, p=0.003). However, frailty did not have an independent impact on PCI (adjusted OR 0.66, 95% CI 0.41–1.08). Frailty was significantly associated with increased risk of having arrhythmia during hospitalisation (adjusted OR 2.24, 95% CI 1.32–3.80), hospital-acquired pneumonia (adjusted OR 2.27, 95% CI 1.24–4.17), in-hospital mortality (adjusted OR 3.02, 95% CI 1.35–6.75), 30-day mortality (adjusted OR 3.28, 95% CI 1.59–6.76), and 30-day readmission (adjusted OR 2.53, 95% CI 1.38–4.63).Conclusion: In this study, frailty was present in nearly half of older patients with ACS and was associated with increased adverse outcomes. These findings suggest that frailty screening should be performed in older patients with ACS in Vietnam.Keywords: frailty, acute coronary syndrome, elderly, older patients, adverse outcomes, Vietnam
format	article
author	Nguyen TV Le D Tran KD Bui KX Nguyen TN
author_facet	Nguyen TV Le D Tran KD Bui KX Nguyen TN
author_sort	Nguyen TV
title	Frailty in Older Patients with Acute Coronary Syndrome in Vietnam
title_short	Frailty in Older Patients with Acute Coronary Syndrome in Vietnam
title_full	Frailty in Older Patients with Acute Coronary Syndrome in Vietnam
title_fullStr	Frailty in Older Patients with Acute Coronary Syndrome in Vietnam
title_full_unstemmed	Frailty in Older Patients with Acute Coronary Syndrome in Vietnam
title_sort	frailty in older patients with acute coronary syndrome in vietnam
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/089da7f1a5b640638db6e0ff300c1755
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Frailty in Older Patients with Acute Coronary Syndrome in Vietnam

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