Caspase-11 signaling enhances graft-versus-host disease

An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11, and provide mechanistic insights into the sig...

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Autores principales:	Yanyan Lu, Ran Meng, Xiangyu Wang, Yajing Xu, Yiting Tang, Jianfeng Wu, Qianqian Xue, Songlin Yu, Mingwu Duan, Dongyong Shan, Qingde Wang, Haichao Wang, Timothy R. Billiar, Xianzhong Xiao, Fangping Chen, Ben Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08a02537b034440a89b0304b0127fb2f
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spelling	oai:doaj.org-article:08a02537b034440a89b0304b0127fb2f2021-12-02T15:35:17ZCaspase-11 signaling enhances graft-versus-host disease10.1038/s41467-019-11895-22041-1723https://doaj.org/article/08a02537b034440a89b0304b0127fb2f2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11895-2https://doaj.org/toc/2041-1723An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11, and provide mechanistic insights into the signals leading to caspase-11 activation in GvHD.Yanyan LuRan MengXiangyu WangYajing XuYiting TangJianfeng WuQianqian XueSonglin YuMingwu DuanDongyong ShanQingde WangHaichao WangTimothy R. BilliarXianzhong XiaoFangping ChenBen LuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanyan Lu Ran Meng Xiangyu Wang Yajing Xu Yiting Tang Jianfeng Wu Qianqian Xue Songlin Yu Mingwu Duan Dongyong Shan Qingde Wang Haichao Wang Timothy R. Billiar Xianzhong Xiao Fangping Chen Ben Lu Caspase-11 signaling enhances graft-versus-host disease
description	An increasing number of inflammatory pathologies is associated with IL-1 production downstream of caspases 1 and 11. Here the authors show that graft-versus-host-disease (GvHD) is diminished in mice with genetic or pharmacological ablation of caspase-11, and provide mechanistic insights into the signals leading to caspase-11 activation in GvHD.
format	article
author	Yanyan Lu Ran Meng Xiangyu Wang Yajing Xu Yiting Tang Jianfeng Wu Qianqian Xue Songlin Yu Mingwu Duan Dongyong Shan Qingde Wang Haichao Wang Timothy R. Billiar Xianzhong Xiao Fangping Chen Ben Lu
author_facet	Yanyan Lu Ran Meng Xiangyu Wang Yajing Xu Yiting Tang Jianfeng Wu Qianqian Xue Songlin Yu Mingwu Duan Dongyong Shan Qingde Wang Haichao Wang Timothy R. Billiar Xianzhong Xiao Fangping Chen Ben Lu
author_sort	Yanyan Lu
title	Caspase-11 signaling enhances graft-versus-host disease
title_short	Caspase-11 signaling enhances graft-versus-host disease
title_full	Caspase-11 signaling enhances graft-versus-host disease
title_fullStr	Caspase-11 signaling enhances graft-versus-host disease
title_full_unstemmed	Caspase-11 signaling enhances graft-versus-host disease
title_sort	caspase-11 signaling enhances graft-versus-host disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/08a02537b034440a89b0304b0127fb2f
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Caspase-11 signaling enhances graft-versus-host disease

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