Dimer Asymmetry and Light Activation Mechanism in <i>Brucella</i> Blue-Light Sensor Histidine Kinase

Bacteria employ two-component systems (TCSs) to sense and respond to changes in their surroundings. At the core of the TCS signaling pathway is the multidomain sensor histidine kinase, where the enzymatic activity of its output domain is allosterically controlled by the input signal perceived by th...

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Autores principales: Jimena Rinaldi, Ignacio Fernández, Heewhan Shin, Gabriela Sycz, Semini Gunawardana, Indika Kumarapperuma, Juan M. Paz, Lisandro H. Otero, María L. Cerutti, Ángeles Zorreguieta, Zhong Ren, Sebastián Klinke, Xiaojing Yang, Fernando A. Goldbaum
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Acceso en línea:https://doaj.org/article/08a49c821c0046f7a784f88ec818881e
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Sumario:Bacteria employ two-component systems (TCSs) to sense and respond to changes in their surroundings. At the core of the TCS signaling pathway is the multidomain sensor histidine kinase, where the enzymatic activity of its output domain is allosterically controlled by the input signal perceived by the sensor domain.