Nuclear receptors connect progenitor transcription factors to cell cycle control

Abstract The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link with the cell cycle is far less understood. Here we in...

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Autores principales:	Marta Neto, Marina Naval-Sánchez, Delphine Potier, Paulo S. Pereira, Dirk Geerts, Stein Aerts, Fernando Casares
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08a605733ca344fb96316614e0f3d52b
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spelling	oai:doaj.org-article:08a605733ca344fb96316614e0f3d52b2021-12-02T15:05:38ZNuclear receptors connect progenitor transcription factors to cell cycle control10.1038/s41598-017-04936-72045-2322https://doaj.org/article/08a605733ca344fb96316614e0f3d52b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04936-7https://doaj.org/toc/2045-2322Abstract The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link with the cell cycle is far less understood. Here we investigate this link in the developing Drosophila eye, where two transcription factors, the MEIS1 homologue hth and the Zn-finger tsh, synergize to stimulate the proliferation of naïve eye progenitors. Experiments combining transcriptomics, open-chromatin profiling, motif analysis and functional assays indicate that these progenitor transcription factors exert a global regulation of the proliferation program. Rather than directly regulating cell cycle genes, they control proliferation through an intermediary layer of nuclear receptors of the ecdysone/estrogen-signaling pathway. This regulatory subnetwork between hth, tsh and nuclear receptors might be conserved from Drosophila to mammals, as we find a significant co-overexpression of their human homologues in specific cancer types.Marta NetoMarina Naval-SánchezDelphine PotierPaulo S. PereiraDirk GeertsStein AertsFernando CasaresNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marta Neto Marina Naval-Sánchez Delphine Potier Paulo S. Pereira Dirk Geerts Stein Aerts Fernando Casares Nuclear receptors connect progenitor transcription factors to cell cycle control
description	Abstract The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link with the cell cycle is far less understood. Here we investigate this link in the developing Drosophila eye, where two transcription factors, the MEIS1 homologue hth and the Zn-finger tsh, synergize to stimulate the proliferation of naïve eye progenitors. Experiments combining transcriptomics, open-chromatin profiling, motif analysis and functional assays indicate that these progenitor transcription factors exert a global regulation of the proliferation program. Rather than directly regulating cell cycle genes, they control proliferation through an intermediary layer of nuclear receptors of the ecdysone/estrogen-signaling pathway. This regulatory subnetwork between hth, tsh and nuclear receptors might be conserved from Drosophila to mammals, as we find a significant co-overexpression of their human homologues in specific cancer types.
format	article
author	Marta Neto Marina Naval-Sánchez Delphine Potier Paulo S. Pereira Dirk Geerts Stein Aerts Fernando Casares
author_facet	Marta Neto Marina Naval-Sánchez Delphine Potier Paulo S. Pereira Dirk Geerts Stein Aerts Fernando Casares
author_sort	Marta Neto
title	Nuclear receptors connect progenitor transcription factors to cell cycle control
title_short	Nuclear receptors connect progenitor transcription factors to cell cycle control
title_full	Nuclear receptors connect progenitor transcription factors to cell cycle control
title_fullStr	Nuclear receptors connect progenitor transcription factors to cell cycle control
title_full_unstemmed	Nuclear receptors connect progenitor transcription factors to cell cycle control
title_sort	nuclear receptors connect progenitor transcription factors to cell cycle control
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/08a605733ca344fb96316614e0f3d52b
work_keys_str_mv	AT martaneto nuclearreceptorsconnectprogenitortranscriptionfactorstocellcyclecontrol AT marinanavalsanchez nuclearreceptorsconnectprogenitortranscriptionfactorstocellcyclecontrol AT delphinepotier nuclearreceptorsconnectprogenitortranscriptionfactorstocellcyclecontrol AT paulospereira nuclearreceptorsconnectprogenitortranscriptionfactorstocellcyclecontrol AT dirkgeerts nuclearreceptorsconnectprogenitortranscriptionfactorstocellcyclecontrol AT steinaerts nuclearreceptorsconnectprogenitortranscriptionfactorstocellcyclecontrol AT fernandocasares nuclearreceptorsconnectprogenitortranscriptionfactorstocellcyclecontrol
_version_	1718388746774118400

Nuclear receptors connect progenitor transcription factors to cell cycle control

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