Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data

Promoter-anchored chromatin interaction (PAI) is a mechanism by which gene expression is regulated, but methods to measure PAIs are costly and currently not scalable. Here, the authors develop an approach by which PAIs can be predicted using summary-level data from methylation QTL studies.

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Autores principales: Yang Wu, Ting Qi, Huanwei Wang, Futao Zhang, Zhili Zheng, Jennifer E. Phillips-Cremins, Ian J. Deary, Allan F. McRae, Naomi R. Wray, Jian Zeng, Jian Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/08b3f8555e2b481cb0c089930895e8c3
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spelling oai:doaj.org-article:08b3f8555e2b481cb0c089930895e8c32021-12-02T15:34:35ZPromoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data10.1038/s41467-020-15587-02041-1723https://doaj.org/article/08b3f8555e2b481cb0c089930895e8c32020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15587-0https://doaj.org/toc/2041-1723Promoter-anchored chromatin interaction (PAI) is a mechanism by which gene expression is regulated, but methods to measure PAIs are costly and currently not scalable. Here, the authors develop an approach by which PAIs can be predicted using summary-level data from methylation QTL studies.Yang WuTing QiHuanwei WangFutao ZhangZhili ZhengJennifer E. Phillips-CreminsIan J. DearyAllan F. McRaeNaomi R. WrayJian ZengJian YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yang Wu
Ting Qi
Huanwei Wang
Futao Zhang
Zhili Zheng
Jennifer E. Phillips-Cremins
Ian J. Deary
Allan F. McRae
Naomi R. Wray
Jian Zeng
Jian Yang
Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
description Promoter-anchored chromatin interaction (PAI) is a mechanism by which gene expression is regulated, but methods to measure PAIs are costly and currently not scalable. Here, the authors develop an approach by which PAIs can be predicted using summary-level data from methylation QTL studies.
format article
author Yang Wu
Ting Qi
Huanwei Wang
Futao Zhang
Zhili Zheng
Jennifer E. Phillips-Cremins
Ian J. Deary
Allan F. McRae
Naomi R. Wray
Jian Zeng
Jian Yang
author_facet Yang Wu
Ting Qi
Huanwei Wang
Futao Zhang
Zhili Zheng
Jennifer E. Phillips-Cremins
Ian J. Deary
Allan F. McRae
Naomi R. Wray
Jian Zeng
Jian Yang
author_sort Yang Wu
title Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
title_short Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
title_full Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
title_fullStr Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
title_full_unstemmed Promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
title_sort promoter-anchored chromatin interactions predicted from genetic analysis of epigenomic data
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/08b3f8555e2b481cb0c089930895e8c3
work_keys_str_mv AT yangwu promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT tingqi promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT huanweiwang promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT futaozhang promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT zhilizheng promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT jenniferephillipscremins promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT ianjdeary promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT allanfmcrae promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT naomirwray promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT jianzeng promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
AT jianyang promoteranchoredchromatininteractionspredictedfromgeneticanalysisofepigenomicdata
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