Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly

Abstract Previous studies on the association between thyroid function and body composition are conflicting and showed strong differences across age groups. Our aim was to clarify age-specific associations of serum thyroid-stimulating hormone (TSH) levels with markers of body composition including bo...

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Autores principales:	Till Ittermann, Marcello R. P. Markus, Martin Bahls, Stephan B. Felix, Antje Steveling, Matthias Nauck, Henry Völzke, Marcus Dörr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08ba24bcf20344d5876874482fdb0726
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spelling	oai:doaj.org-article:08ba24bcf20344d5876874482fdb07262021-12-02T14:58:32ZLow serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly10.1038/s41598-021-90178-72045-2322https://doaj.org/article/08ba24bcf20344d5876874482fdb07262021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90178-7https://doaj.org/toc/2045-2322Abstract Previous studies on the association between thyroid function and body composition are conflicting and showed strong differences across age groups. Our aim was to clarify age-specific associations of serum thyroid-stimulating hormone (TSH) levels with markers of body composition including body mass index (BMI), waist circumference, fat mass (FM), fat-free mass (FFM) and body cell mass (BCM). We used data from two independent population-based cohorts within the framework of the Study of Health in Pomerania. The study population included 5656 individuals aged 20 to 90 years. Markers of body composition were measured by bioelectrical impedance analysis. Serum TSH levels were significantly positively associated with BMI (β = 0.16; 95% confidence interval [CI]: 0.06 to 0.27), waist circumference (β = 0.35; 95% CI: 0.08 to 0.62) and FM (β = 0.32; 95% CI: 0.12 to 0.52), but not with FFM and BCM. Interaction analysis revealed positive associations of serum TSH levels with BMI, waist circumference, FM, FFM and BCM in individuals older than 60 years, while no such associations were observed in younger individuals. We demonstrated that lower serum TSH levels were accompanied with lower values of BMI, waist circumference, FM, FFM, and BCM in the elderly, while no such associations were observed in younger individuals.Till IttermannMarcello R. P. MarkusMartin BahlsStephan B. FelixAntje StevelingMatthias NauckHenry VölzkeMarcus DörrNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Till Ittermann Marcello R. P. Markus Martin Bahls Stephan B. Felix Antje Steveling Matthias Nauck Henry Völzke Marcus Dörr Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly
description	Abstract Previous studies on the association between thyroid function and body composition are conflicting and showed strong differences across age groups. Our aim was to clarify age-specific associations of serum thyroid-stimulating hormone (TSH) levels with markers of body composition including body mass index (BMI), waist circumference, fat mass (FM), fat-free mass (FFM) and body cell mass (BCM). We used data from two independent population-based cohorts within the framework of the Study of Health in Pomerania. The study population included 5656 individuals aged 20 to 90 years. Markers of body composition were measured by bioelectrical impedance analysis. Serum TSH levels were significantly positively associated with BMI (β = 0.16; 95% confidence interval [CI]: 0.06 to 0.27), waist circumference (β = 0.35; 95% CI: 0.08 to 0.62) and FM (β = 0.32; 95% CI: 0.12 to 0.52), but not with FFM and BCM. Interaction analysis revealed positive associations of serum TSH levels with BMI, waist circumference, FM, FFM and BCM in individuals older than 60 years, while no such associations were observed in younger individuals. We demonstrated that lower serum TSH levels were accompanied with lower values of BMI, waist circumference, FM, FFM, and BCM in the elderly, while no such associations were observed in younger individuals.
format	article
author	Till Ittermann Marcello R. P. Markus Martin Bahls Stephan B. Felix Antje Steveling Matthias Nauck Henry Völzke Marcus Dörr
author_facet	Till Ittermann Marcello R. P. Markus Martin Bahls Stephan B. Felix Antje Steveling Matthias Nauck Henry Völzke Marcus Dörr
author_sort	Till Ittermann
title	Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly
title_short	Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly
title_full	Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly
title_fullStr	Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly
title_full_unstemmed	Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly
title_sort	low serum tsh levels are associated with low values of fat-free mass and body cell mass in the elderly
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/08ba24bcf20344d5876874482fdb0726
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Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly

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