CTCF and transcription influence chromatin structure re-configuration after mitosis

Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations of compartmental interactions after mitosis. Furth...

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Autores principales:	Haoyue Zhang, Jessica Lam, Di Zhang, Yemin Lan, Marit W. Vermunt, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08ba3d74d9e640238388f116decac99f
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spelling	oai:doaj.org-article:08ba3d74d9e640238388f116decac99f2021-12-02T19:02:28ZCTCF and transcription influence chromatin structure re-configuration after mitosis10.1038/s41467-021-25418-52041-1723https://doaj.org/article/08ba3d74d9e640238388f116decac99f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25418-5https://doaj.org/toc/2041-1723Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations of compartmental interactions after mitosis. Furthermore, they show global 3D architecture is set up without transcription, but that transcription contributes to proper gene domain formation.Haoyue ZhangJessica LamDi ZhangYemin LanMarit W. VermuntCheryl A. KellerBelinda GiardineRoss C. HardisonGerd A. BlobelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Haoyue Zhang Jessica Lam Di Zhang Yemin Lan Marit W. Vermunt Cheryl A. Keller Belinda Giardine Ross C. Hardison Gerd A. Blobel CTCF and transcription influence chromatin structure re-configuration after mitosis
description	Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations of compartmental interactions after mitosis. Furthermore, they show global 3D architecture is set up without transcription, but that transcription contributes to proper gene domain formation.
format	article
author	Haoyue Zhang Jessica Lam Di Zhang Yemin Lan Marit W. Vermunt Cheryl A. Keller Belinda Giardine Ross C. Hardison Gerd A. Blobel
author_facet	Haoyue Zhang Jessica Lam Di Zhang Yemin Lan Marit W. Vermunt Cheryl A. Keller Belinda Giardine Ross C. Hardison Gerd A. Blobel
author_sort	Haoyue Zhang
title	CTCF and transcription influence chromatin structure re-configuration after mitosis
title_short	CTCF and transcription influence chromatin structure re-configuration after mitosis
title_full	CTCF and transcription influence chromatin structure re-configuration after mitosis
title_fullStr	CTCF and transcription influence chromatin structure re-configuration after mitosis
title_full_unstemmed	CTCF and transcription influence chromatin structure re-configuration after mitosis
title_sort	ctcf and transcription influence chromatin structure re-configuration after mitosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/08ba3d74d9e640238388f116decac99f
work_keys_str_mv	AT haoyuezhang ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis AT jessicalam ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis AT dizhang ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis AT yeminlan ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis AT maritwvermunt ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis AT cherylakeller ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis AT belindagiardine ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis AT rosschardison ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis AT gerdablobel ctcfandtranscriptioninfluencechromatinstructurereconfigurationaftermitosis
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CTCF and transcription influence chromatin structure re-configuration after mitosis

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