Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break

Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break

Polymerase μ (Polμ) participates in the repair of DNA double-strand breaks (DSBs) via the nonhomologous end-joining (NHEJ) pathway. Here, the authors determine the crystal structure of a pre-catalytic ternary complex of human Polμ with a bound DSB substrate and they obtain further mechanistic insigh...

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Autores principales: Andrea M. Kaminski, John M. Pryor, Dale A. Ramsden, Thomas A. Kunkel, Lars C. Pedersen, Katarzyna Bebenek
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/08bcf0ae3cab403fbdaf9bdc81fef324
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