Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases

In budding yeast, the 53BP1 ortholog Rad9 limits the resection nucleolytic processing of DNA double strand breaks. Here the authors reveal that Rad9 promotes long tract gene conversions, BIR and CO, during the HR repair of a DSB via modulation of Sgs1 and Mph1 helicases.

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Autores principales:	Matteo Ferrari, Chetan C. Rawal, Samuele Lodovichi, Maria Y. Vietri, Achille Pellicioli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08beea997c6d4a558a57c65b6a2aa622
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spelling	oai:doaj.org-article:08beea997c6d4a558a57c65b6a2aa6222021-12-02T16:06:04ZRad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases10.1038/s41467-020-16997-w2041-1723https://doaj.org/article/08beea997c6d4a558a57c65b6a2aa6222020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16997-whttps://doaj.org/toc/2041-1723In budding yeast, the 53BP1 ortholog Rad9 limits the resection nucleolytic processing of DNA double strand breaks. Here the authors reveal that Rad9 promotes long tract gene conversions, BIR and CO, during the HR repair of a DSB via modulation of Sgs1 and Mph1 helicases.Matteo FerrariChetan C. RawalSamuele LodovichiMaria Y. VietriAchille PellicioliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo Ferrari Chetan C. Rawal Samuele Lodovichi Maria Y. Vietri Achille Pellicioli Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
description	In budding yeast, the 53BP1 ortholog Rad9 limits the resection nucleolytic processing of DNA double strand breaks. Here the authors reveal that Rad9 promotes long tract gene conversions, BIR and CO, during the HR repair of a DSB via modulation of Sgs1 and Mph1 helicases.
format	article
author	Matteo Ferrari Chetan C. Rawal Samuele Lodovichi Maria Y. Vietri Achille Pellicioli
author_facet	Matteo Ferrari Chetan C. Rawal Samuele Lodovichi Maria Y. Vietri Achille Pellicioli
author_sort	Matteo Ferrari
title	Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
title_short	Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
title_full	Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
title_fullStr	Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
title_full_unstemmed	Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases
title_sort	rad9/53bp1 promotes dna repair via crossover recombination by limiting the sgs1 and mph1 helicases
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/08beea997c6d4a558a57c65b6a2aa622
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Rad9/53BP1 promotes DNA repair via crossover recombination by limiting the Sgs1 and Mph1 helicases

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