The Profile and Function of Gut Microbiota in Diabetic Nephropathy

Weihong Chen,1 Mengjiu Zhang,1 Yan Guo,1 Zhen Wang,1 Qingqing Liu,1 Runze Yan,1 Yi Wang,1 Qiaoru Wu,1 Kai Yuan,2 Weiwei Sun1 1Department of Nephrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People’s Republic of China; 2School of Life Sciences, Beijing Universi...

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Autores principales:	Chen W, Zhang M, Guo Y, Wang Z, Liu Q, Yan R, Wang Y, Wu Q, Yuan K, Sun W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetic nephropathy gut microbiota genus progression Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/08c1e6f734c54499beba0af5e3338e23
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spelling	oai:doaj.org-article:08c1e6f734c54499beba0af5e3338e232021-12-02T19:21:58ZThe Profile and Function of Gut Microbiota in Diabetic Nephropathy1178-7007https://doaj.org/article/08c1e6f734c54499beba0af5e3338e232021-10-01T00:00:00Zhttps://www.dovepress.com/the-profile-and-function-of-gut-microbiota-in-diabetic-nephropathy-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Weihong Chen,1 Mengjiu Zhang,1 Yan Guo,1 Zhen Wang,1 Qingqing Liu,1 Runze Yan,1 Yi Wang,1 Qiaoru Wu,1 Kai Yuan,2 Weiwei Sun1 1Department of Nephrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People’s Republic of China; 2School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of ChinaCorrespondence: Kai Yuan; Weiwei Sun Email yuankai@bucm.edu.cn; sunweitcm@163.comIntroduction: Dysbiosis of gut microbiota impairs the homeostasis of immune and metabolic systems. Although previous studies have revealed the correlation between gut microbiota and various diseases, the function between gut microbiota and diabetic nephropathy (DN) has not been discovered distinctly. In this study, we tried to investigate the profile and function of gut microbiota in DN.Methods: A total of 100 people were enrolled in this study. Twenty were healthy people, 20 were diabetes patients, and 60 were DN patients. The DN patients were divided into three stages including stage III, IV, and V. We conducted taxonomic analyses in different groups. The distributions of phyla, classes, orders, families, and genera in different groups and samples were investigated. We also evaluated the correlations between clinical parameters and gut microbiota in 60 DN patients.Results: The gut microbiota in the healthy group, diabetes group, and DN group had 1764 operational taxonomic units (OTUs) in total. The healthy group had 1034 OTUs, the diabetes group had 899 OTUs, and the DN group had 1602 OTUs. The diversity of gut microbiota in the stage III DN group was smaller than that in the other groups. 24-h urinary protein was positively correlated with Alistipes and Subdoligranulum, cholesterol was positively correlated with Bacteroides and Lachnoclostridium, and estimated glomerular filtration rate was negatively correlated with Ruminococcus torques group.Discussion: The gut microbiota might play an important role in the development and pathogenesis of DN. A change in gut microbiota diversity is correlated with disease progression. Some kinds of gut microbiota including Alistipes, Bacteroides, Subdoligranulum, Lachnoclostridium, and Ruminococcus torques group might be detrimental factors in DN.Keywords: diabetic nephropathy, gut microbiota, genus, progressionChen WZhang MGuo YWang ZLiu QYan RWang YWu QYuan KSun WDove Medical Pressarticlediabetic nephropathygut microbiotagenusprogressionSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4283-4296 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic nephropathy gut microbiota genus progression Specialties of internal medicine RC581-951
spellingShingle	diabetic nephropathy gut microbiota genus progression Specialties of internal medicine RC581-951 Chen W Zhang M Guo Y Wang Z Liu Q Yan R Wang Y Wu Q Yuan K Sun W The Profile and Function of Gut Microbiota in Diabetic Nephropathy
description	Weihong Chen,1 Mengjiu Zhang,1 Yan Guo,1 Zhen Wang,1 Qingqing Liu,1 Runze Yan,1 Yi Wang,1 Qiaoru Wu,1 Kai Yuan,2 Weiwei Sun1 1Department of Nephrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People’s Republic of China; 2School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of ChinaCorrespondence: Kai Yuan; Weiwei Sun Email yuankai@bucm.edu.cn; sunweitcm@163.comIntroduction: Dysbiosis of gut microbiota impairs the homeostasis of immune and metabolic systems. Although previous studies have revealed the correlation between gut microbiota and various diseases, the function between gut microbiota and diabetic nephropathy (DN) has not been discovered distinctly. In this study, we tried to investigate the profile and function of gut microbiota in DN.Methods: A total of 100 people were enrolled in this study. Twenty were healthy people, 20 were diabetes patients, and 60 were DN patients. The DN patients were divided into three stages including stage III, IV, and V. We conducted taxonomic analyses in different groups. The distributions of phyla, classes, orders, families, and genera in different groups and samples were investigated. We also evaluated the correlations between clinical parameters and gut microbiota in 60 DN patients.Results: The gut microbiota in the healthy group, diabetes group, and DN group had 1764 operational taxonomic units (OTUs) in total. The healthy group had 1034 OTUs, the diabetes group had 899 OTUs, and the DN group had 1602 OTUs. The diversity of gut microbiota in the stage III DN group was smaller than that in the other groups. 24-h urinary protein was positively correlated with Alistipes and Subdoligranulum, cholesterol was positively correlated with Bacteroides and Lachnoclostridium, and estimated glomerular filtration rate was negatively correlated with Ruminococcus torques group.Discussion: The gut microbiota might play an important role in the development and pathogenesis of DN. A change in gut microbiota diversity is correlated with disease progression. Some kinds of gut microbiota including Alistipes, Bacteroides, Subdoligranulum, Lachnoclostridium, and Ruminococcus torques group might be detrimental factors in DN.Keywords: diabetic nephropathy, gut microbiota, genus, progression
format	article
author	Chen W Zhang M Guo Y Wang Z Liu Q Yan R Wang Y Wu Q Yuan K Sun W
author_facet	Chen W Zhang M Guo Y Wang Z Liu Q Yan R Wang Y Wu Q Yuan K Sun W
author_sort	Chen W
title	The Profile and Function of Gut Microbiota in Diabetic Nephropathy
title_short	The Profile and Function of Gut Microbiota in Diabetic Nephropathy
title_full	The Profile and Function of Gut Microbiota in Diabetic Nephropathy
title_fullStr	The Profile and Function of Gut Microbiota in Diabetic Nephropathy
title_full_unstemmed	The Profile and Function of Gut Microbiota in Diabetic Nephropathy
title_sort	profile and function of gut microbiota in diabetic nephropathy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/08c1e6f734c54499beba0af5e3338e23
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The Profile and Function of Gut Microbiota in Diabetic Nephropathy

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