Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review

Yuan-Yun Tseng,1 Tai-Yuan Chen,2 Shih-Jung Liu3,4 1Department of Neurosurgery, New Taipei Municipal Tu-Cheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei City, Taiwan; 2Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Ta...

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Autores principales:	Tseng YY, Chen TY, Liu SJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	malignant glioma chemoresistance local delivery nanofiber nanoparticle focused ultrasound magnetic nanoparticles Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/08c5d1f876344a3db268bec975fa8b1b
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spelling	oai:doaj.org-article:08c5d1f876344a3db268bec975fa8b1b2021-12-02T18:47:42ZRole of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review1178-2013https://doaj.org/article/08c5d1f876344a3db268bec975fa8b1b2021-07-01T00:00:00Zhttps://www.dovepress.com/role-of-polymeric-local-drug-delivery-in-multimodal-treatment-of-malig-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Yuan-Yun Tseng,1 Tai-Yuan Chen,2 Shih-Jung Liu3,4 1Department of Neurosurgery, New Taipei Municipal Tu-Cheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei City, Taiwan; 2Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan; 4Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkuo, Tao-Yuan, TaiwanCorrespondence: Shih-Jung LiuBiomaterials Lab, Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302, TaiwanTel +886-3-2118611Fax +886-3-2118558Email profsjliu5347@gmail.comAbstract: Malignant gliomas (MGs) are the most common and devastating primary brain tumor. At present, surgical interventions, radiotherapy, and chemotherapy are only marginally effective in prolonging the life expectancy of patients with MGs. Inherent heterogeneity, aggressive invasion and infiltration, intact physical barriers, and the numerous mechanisms underlying chemotherapy and radiotherapy resistance contribute to the poor prognosis for patients with MGs. Various studies have investigated methods to overcome these obstacles in MG treatment. In this review, we address difficulties in MG treatment and focus on promising polymeric local drug delivery systems. In contrast to most local delivery systems, which are directly implanted into the residual cavity after intratumoral injection or the surgical removal of a tumor, some rapidly developing and promising nanotechnological methods—including surface-decorated nanoparticles, magnetic nanoparticles, and focused ultrasound assist transport—are administered through (systemic) intravascular injection. We also discuss further synergistic and multimodal strategies for heightening therapeutic efficacy. Finally, we outline the challenges and therapeutic potential of these polymeric drug delivery systems.Keywords: malignant glioma, chemoresistance, local delivery, nanofiber, nanoparticle, focused ultrasound, magnetic nanoparticlesTseng YYChen TYLiu SJDove Medical Pressarticlemalignant gliomachemoresistancelocal deliverynanofibernanoparticlefocused ultrasoundmagnetic nanoparticlesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 4597-4614 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malignant glioma chemoresistance local delivery nanofiber nanoparticle focused ultrasound magnetic nanoparticles Medicine (General) R5-920
spellingShingle	malignant glioma chemoresistance local delivery nanofiber nanoparticle focused ultrasound magnetic nanoparticles Medicine (General) R5-920 Tseng YY Chen TY Liu SJ Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review
description	Yuan-Yun Tseng,1 Tai-Yuan Chen,2 Shih-Jung Liu3,4 1Department of Neurosurgery, New Taipei Municipal Tu-Cheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei City, Taiwan; 2Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 3Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan; 4Department of Orthopedic Surgery, Chang Gung Memorial Hospital-Linkuo, Tao-Yuan, TaiwanCorrespondence: Shih-Jung LiuBiomaterials Lab, Mechanical Engineering, Chang Gung University, 259, Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 33302, TaiwanTel +886-3-2118611Fax +886-3-2118558Email profsjliu5347@gmail.comAbstract: Malignant gliomas (MGs) are the most common and devastating primary brain tumor. At present, surgical interventions, radiotherapy, and chemotherapy are only marginally effective in prolonging the life expectancy of patients with MGs. Inherent heterogeneity, aggressive invasion and infiltration, intact physical barriers, and the numerous mechanisms underlying chemotherapy and radiotherapy resistance contribute to the poor prognosis for patients with MGs. Various studies have investigated methods to overcome these obstacles in MG treatment. In this review, we address difficulties in MG treatment and focus on promising polymeric local drug delivery systems. In contrast to most local delivery systems, which are directly implanted into the residual cavity after intratumoral injection or the surgical removal of a tumor, some rapidly developing and promising nanotechnological methods—including surface-decorated nanoparticles, magnetic nanoparticles, and focused ultrasound assist transport—are administered through (systemic) intravascular injection. We also discuss further synergistic and multimodal strategies for heightening therapeutic efficacy. Finally, we outline the challenges and therapeutic potential of these polymeric drug delivery systems.Keywords: malignant glioma, chemoresistance, local delivery, nanofiber, nanoparticle, focused ultrasound, magnetic nanoparticles
format	article
author	Tseng YY Chen TY Liu SJ
author_facet	Tseng YY Chen TY Liu SJ
author_sort	Tseng YY
title	Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review
title_short	Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review
title_full	Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review
title_fullStr	Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review
title_full_unstemmed	Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review
title_sort	role of polymeric local drug delivery in multimodal treatment of malignant glioma: a review
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/08c5d1f876344a3db268bec975fa8b1b
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Role of Polymeric Local Drug Delivery in Multimodal Treatment of Malignant Glioma: A Review

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