Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair

Growth plate cartilage has limited self-repair ability, leading to poor bone bridge formation post-injury and ultimately limb growth defects in children. The current corrective surgeries are highly invasive, and outcomes can be unpredictable. Following growth plate injury, the direct loss of extrace...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pengfei Guan, Can Liu, Denghui Xie, Shichao Mao, Yuelun Ji, Yongchang Lin, Zheng Chen, Qiyou Wang, Lei Fan, Yongjian Sun
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Extracellular matrix-mimic hydrogel Exosomes Immunomodulatory Extracellular matrix deposition Growth plate injury repair Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/08cc9f3a9740408db5b90e8b1ee37faa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:08cc9f3a9740408db5b90e8b1ee37faa
record_format	dspace
spelling	oai:doaj.org-article:08cc9f3a9740408db5b90e8b1ee37faa2021-11-26T04:37:09ZExosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair2452-199X10.1016/j.bioactmat.2021.09.010https://doaj.org/article/08cc9f3a9740408db5b90e8b1ee37faa2022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21004205https://doaj.org/toc/2452-199XGrowth plate cartilage has limited self-repair ability, leading to poor bone bridge formation post-injury and ultimately limb growth defects in children. The current corrective surgeries are highly invasive, and outcomes can be unpredictable. Following growth plate injury, the direct loss of extracellular matrix (ECM) coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration. We designed an exosome (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) loaded ECM-mimic hydrogel to promote cartilage repair by directly supplementing ECM and anti-inflammatory properties. Aldehyde-functionalized chondroitin sulfate (OCS) was introduced into gelatin methacryloyl (GM) to form GMOCS hydrogel. Our results uncovered that GMOCS hydrogel could significantly promote the synthesis of ECM due to the doping of OCS. In addition, the GMOCS-Exos hydrogel could further promote the anabolism of chondrocytes by inhibiting inflammation and ultimately promote growth plate injury repair through ECM remodeling.Pengfei GuanCan LiuDenghui XieShichao MaoYuelun JiYongchang LinZheng ChenQiyou WangLei FanYongjian SunKeAi Communications Co., Ltd.articleExtracellular matrix-mimic hydrogelExosomesImmunomodulatoryExtracellular matrix depositionGrowth plate injury repairMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 145-158 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Extracellular matrix-mimic hydrogel Exosomes Immunomodulatory Extracellular matrix deposition Growth plate injury repair Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Extracellular matrix-mimic hydrogel Exosomes Immunomodulatory Extracellular matrix deposition Growth plate injury repair Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair
description	Growth plate cartilage has limited self-repair ability, leading to poor bone bridge formation post-injury and ultimately limb growth defects in children. The current corrective surgeries are highly invasive, and outcomes can be unpredictable. Following growth plate injury, the direct loss of extracellular matrix (ECM) coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration. We designed an exosome (Exo) derived from bone marrow mesenchymal stem cells (BMSCs) loaded ECM-mimic hydrogel to promote cartilage repair by directly supplementing ECM and anti-inflammatory properties. Aldehyde-functionalized chondroitin sulfate (OCS) was introduced into gelatin methacryloyl (GM) to form GMOCS hydrogel. Our results uncovered that GMOCS hydrogel could significantly promote the synthesis of ECM due to the doping of OCS. In addition, the GMOCS-Exos hydrogel could further promote the anabolism of chondrocytes by inhibiting inflammation and ultimately promote growth plate injury repair through ECM remodeling.
format	article
author	Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun
author_facet	Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun
author_sort	Pengfei Guan
title	Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair
title_short	Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair
title_full	Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair
title_fullStr	Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair
title_full_unstemmed	Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair
title_sort	exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property facilitates/promotes growth plate injury repair
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/08cc9f3a9740408db5b90e8b1ee37faa
work_keys_str_mv	AT pengfeiguan exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT canliu exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT denghuixie exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT shichaomao exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT yuelunji exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT yongchanglin exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT zhengchen exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT qiyouwang exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT leifan exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair AT yongjiansun exosomeloadedextracellularmatrixmimichydrogelwithantiinflammatorypropertyfacilitatespromotesgrowthplateinjuryrepair
_version_	1718409822209048576

Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair

Ejemplares similares