Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
Ramanujam Karthikeyan,1 Ganapathy Marimuthu,1 Chellamuthu Ramasubramanian,2 Gautham Arunachal,2 Ahmed S BaHammam,3 David Warren Spence,4 Daniel P Cardinali,5 Gregory M Brown,6 Seithikurippu R Pandi-Perumal7 1Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kama...
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Dove Medical Press
2014
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oai:doaj.org-article:08d2b4f760d54eab91e71c6a9c1ec0492021-12-02T08:45:04ZAssociation of Per3 length polymorphism with bipolar I disorder and schizophrenia1178-2021https://doaj.org/article/08d2b4f760d54eab91e71c6a9c1ec0492014-12-01T00:00:00Zhttp://www.dovepress.com/association-of-per3-length-polymorphism-withnbspbipolar-i-disorder-and-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Ramanujam Karthikeyan,1 Ganapathy Marimuthu,1 Chellamuthu Ramasubramanian,2 Gautham Arunachal,2 Ahmed S BaHammam,3 David Warren Spence,4 Daniel P Cardinali,5 Gregory M Brown,6 Seithikurippu R Pandi-Perumal7 1Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India; 2MS Chellamuthu Trust and Research Foundation, KK Nagar, Madurai, India; 3University Sleep Disorders Center, College of Medicine, National Plan for Science and Technology, King Saud University, Riyadh, Saudi Arabia; 4Independent researcher, Toronto, Ontario, Canada; 5Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina; 6Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; 7Center for Healthful Behavior Change (CHBC), Division of Health and Behavior, Department of Population Health, NYU Langone Medical Center, Clinical and Translational Research Institute, New York, New York, USA Background: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India.Methods: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers.Results: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ2=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls.Conclusion: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group. Keywords: circadian rhythms, clock genes, Per3 polymorphism, bipolar disorder, schizo­phreniaKarthikeyan RMarimuthu GRamasubramanian CArunachal GBaHammam ASSpence DWCardinali DPBrown GMPandi-Perumal SRDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 2325-2330 (2014) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Karthikeyan R Marimuthu G Ramasubramanian C Arunachal G BaHammam AS Spence DW Cardinali DP Brown GM Pandi-Perumal SR Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
| description |
Ramanujam Karthikeyan,1 Ganapathy Marimuthu,1 Chellamuthu Ramasubramanian,2 Gautham Arunachal,2 Ahmed S BaHammam,3 David Warren Spence,4 Daniel P Cardinali,5 Gregory M Brown,6 Seithikurippu R Pandi-Perumal7 1Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India; 2MS Chellamuthu Trust and Research Foundation, KK Nagar, Madurai, India; 3University Sleep Disorders Center, College of Medicine, National Plan for Science and Technology, King Saud University, Riyadh, Saudi Arabia; 4Independent researcher, Toronto, Ontario, Canada; 5Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina; 6Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada; 7Center for Healthful Behavior Change (CHBC), Division of Health and Behavior, Department of Population Health, NYU Langone Medical Center, Clinical and Translational Research Institute, New York, New York, USA Background: Sleep–wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India.Methods: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers.Results: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08–2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ2=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls.Conclusion: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group. Keywords: circadian rhythms, clock genes, Per3 polymorphism, bipolar disorder, schizo­phrenia |
| format |
article |
| author |
Karthikeyan R Marimuthu G Ramasubramanian C Arunachal G BaHammam AS Spence DW Cardinali DP Brown GM Pandi-Perumal SR |
| author_facet |
Karthikeyan R Marimuthu G Ramasubramanian C Arunachal G BaHammam AS Spence DW Cardinali DP Brown GM Pandi-Perumal SR |
| author_sort |
Karthikeyan R |
| title |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
| title_short |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
| title_full |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
| title_fullStr |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
| title_full_unstemmed |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
| title_sort |
association of per3 length polymorphism with bipolar i disorder and schizophrenia |
| publisher |
Dove Medical Press |
| publishDate |
2014 |
| url |
https://doaj.org/article/08d2b4f760d54eab91e71c6a9c1ec049 |
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