Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.

Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.

Hepatitis C virus (HCV) is a genetically diverse pathogen infecting approximately 2-3% of the world's population. Herein, we describe results of a large, multicentre serological and molecular epidemiological study cataloguing the prevalence and genetic diversity of HCV in five regions of Vietna...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Linda Dunford, Michael J Carr, Jonathan Dean, Allison Waters, Linh Thuy Nguyen, Thu Hong Ta Thi, Lan Anh Bui Thi, Huy Duong Do, Thu Thuy Duong Thi, Ha Thu Nguyen, Trinh Thi Diem Do, Quynh Phuong Luu, Jeff Connell, Suzie Coughlan, Hien Tran Nguyen, William W Hall, Lan Anh Nguyen Thi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/08d3b74756d949408a35e9d1e4cbc37f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:08d3b74756d949408a35e9d1e4cbc37f
record_format dspace
spelling oai:doaj.org-article:08d3b74756d949408a35e9d1e4cbc37f2021-11-18T07:08:45ZHepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.1932-620310.1371/journal.pone.0041266https://doaj.org/article/08d3b74756d949408a35e9d1e4cbc37f2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22916104/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Hepatitis C virus (HCV) is a genetically diverse pathogen infecting approximately 2-3% of the world's population. Herein, we describe results of a large, multicentre serological and molecular epidemiological study cataloguing the prevalence and genetic diversity of HCV in five regions of Vietnam; Ha Noi, Hai Phong, Da Nang, Khanh Hoa and Can Tho. Individuals (n=8654) with varying risk factors for infection were analysed for the presence of HCV Ab/Ag and, in a subset of positive specimens, for HCV RNA levels (n=475) and genotype (n=282). In lower risk individuals, including voluntary blood donors, military recruits and pregnant women, the prevalence of infection was 0.5% (n=26/5250). Prevalence rates were significantly higher (p<0.001) in intravenous drug users (IDUs; 55.6%, n=556/1000), dialysis patients (26.6%, n=153/575) commercial sex workers (CSWs; 8.7%, n=87/1000), and recipients of multiple blood transfusions (6.0%, n=32/529). The prevalence of HCV in dialysis patients varied but remained high in all regions (11-43%) and was associated with the receipt of blood transfusions [OR: 2.08 (1.85-2.34), p=0.001], time from first transfusion [OR: 1.07 (1.01-1.13), p=0.023], duration of dialysis [OR: 1.31 (1.19-1.43), p<0.001] and male gender [OR: 1.60 (1.06-2.41), p=0.026]. Phylogenetic analysis revealed high genetic diversity, particularly amongst dialysis and multi-transfused patients, identifying subtypes 1a (33%), 1b (27%), 2a (0.4%), 3a (0.7%), 3b (1.1%), 6a (18.8%), 6e (6.0%), 6h (4.6%), 6l (6.4%) and 2 clusters of novel genotype 6 variants (2.1%). HCV genotype 1 predominated in Vietnam (60%, n=169/282) but the proportion of infections attributable to genotype 1 varied between regions and risk groups and, in the Southern part of Vietnam, genotype 6 viruses dominated in dialysis and multi-transfused patients (73.9%). This study confirms a high prevalence of HCV infection in Vietnamese IDUs and, notably, reveals high levels of HCV infection associated with dialysis and blood transfusion.Linda DunfordMichael J CarrJonathan DeanAllison WatersLinh Thuy NguyenThu Hong Ta ThiLan Anh Bui ThiHuy Duong DoThu Thuy Duong ThiHa Thu NguyenTrinh Thi Diem DoQuynh Phuong LuuJeff ConnellSuzie CoughlanHien Tran NguyenWilliam W HallLan Anh Nguyen ThiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e41266 (2012)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Linda Dunford
Michael J Carr
Jonathan Dean
Allison Waters
Linh Thuy Nguyen
Thu Hong Ta Thi
Lan Anh Bui Thi
Huy Duong Do
Thu Thuy Duong Thi
Ha Thu Nguyen
Trinh Thi Diem Do
Quynh Phuong Luu
Jeff Connell
Suzie Coughlan
Hien Tran Nguyen
William W Hall
Lan Anh Nguyen Thi
Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.
description Hepatitis C virus (HCV) is a genetically diverse pathogen infecting approximately 2-3% of the world's population. Herein, we describe results of a large, multicentre serological and molecular epidemiological study cataloguing the prevalence and genetic diversity of HCV in five regions of Vietnam; Ha Noi, Hai Phong, Da Nang, Khanh Hoa and Can Tho. Individuals (n=8654) with varying risk factors for infection were analysed for the presence of HCV Ab/Ag and, in a subset of positive specimens, for HCV RNA levels (n=475) and genotype (n=282). In lower risk individuals, including voluntary blood donors, military recruits and pregnant women, the prevalence of infection was 0.5% (n=26/5250). Prevalence rates were significantly higher (p<0.001) in intravenous drug users (IDUs; 55.6%, n=556/1000), dialysis patients (26.6%, n=153/575) commercial sex workers (CSWs; 8.7%, n=87/1000), and recipients of multiple blood transfusions (6.0%, n=32/529). The prevalence of HCV in dialysis patients varied but remained high in all regions (11-43%) and was associated with the receipt of blood transfusions [OR: 2.08 (1.85-2.34), p=0.001], time from first transfusion [OR: 1.07 (1.01-1.13), p=0.023], duration of dialysis [OR: 1.31 (1.19-1.43), p<0.001] and male gender [OR: 1.60 (1.06-2.41), p=0.026]. Phylogenetic analysis revealed high genetic diversity, particularly amongst dialysis and multi-transfused patients, identifying subtypes 1a (33%), 1b (27%), 2a (0.4%), 3a (0.7%), 3b (1.1%), 6a (18.8%), 6e (6.0%), 6h (4.6%), 6l (6.4%) and 2 clusters of novel genotype 6 variants (2.1%). HCV genotype 1 predominated in Vietnam (60%, n=169/282) but the proportion of infections attributable to genotype 1 varied between regions and risk groups and, in the Southern part of Vietnam, genotype 6 viruses dominated in dialysis and multi-transfused patients (73.9%). This study confirms a high prevalence of HCV infection in Vietnamese IDUs and, notably, reveals high levels of HCV infection associated with dialysis and blood transfusion.
format article
author Linda Dunford
Michael J Carr
Jonathan Dean
Allison Waters
Linh Thuy Nguyen
Thu Hong Ta Thi
Lan Anh Bui Thi
Huy Duong Do
Thu Thuy Duong Thi
Ha Thu Nguyen
Trinh Thi Diem Do
Quynh Phuong Luu
Jeff Connell
Suzie Coughlan
Hien Tran Nguyen
William W Hall
Lan Anh Nguyen Thi
author_facet Linda Dunford
Michael J Carr
Jonathan Dean
Allison Waters
Linh Thuy Nguyen
Thu Hong Ta Thi
Lan Anh Bui Thi
Huy Duong Do
Thu Thuy Duong Thi
Ha Thu Nguyen
Trinh Thi Diem Do
Quynh Phuong Luu
Jeff Connell
Suzie Coughlan
Hien Tran Nguyen
William W Hall
Lan Anh Nguyen Thi
author_sort Linda Dunford
title Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.
title_short Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.
title_full Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.
title_fullStr Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.
title_full_unstemmed Hepatitis C virus in Vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.
title_sort hepatitis c virus in vietnam: high prevalence of infection in dialysis and multi-transfused patients involving diverse and novel virus variants.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/08d3b74756d949408a35e9d1e4cbc37f
work_keys_str_mv AT lindadunford hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT michaeljcarr hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT jonathandean hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT allisonwaters hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT linhthuynguyen hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT thuhongtathi hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT lananhbuithi hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT huyduongdo hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT thuthuyduongthi hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT hathunguyen hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT trinhthidiemdo hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT quynhphuongluu hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT jeffconnell hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT suziecoughlan hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT hientrannguyen hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT williamwhall hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
AT lananhnguyenthi hepatitiscvirusinvietnamhighprevalenceofinfectionindialysisandmultitransfusedpatientsinvolvingdiverseandnovelvirusvariants
_version_ 1718423834387808256

Ejemplares similares