Global emergence and evolutionary dynamics of bluetongue virus

Abstract Bluetongue virus (BTV) epidemics are responsible for worldwide economic losses of up to US$ 3 billion. Understanding the global evolutionary epidemiology of BTV is critical in designing intervention programs. Here we employed phylodynamic models to quantify the evolutionary characteristics,...

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Autores principales:	Moh A. Alkhamis, Cecilia Aguilar-Vega, Nicholas M. Fountain-Jones, Kai Lin, Andres M. Perez, José M. Sánchez-Vizcaíno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08d400836ef3439bac794dd77fdc733c
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spelling	oai:doaj.org-article:08d400836ef3439bac794dd77fdc733c2021-12-02T16:18:05ZGlobal emergence and evolutionary dynamics of bluetongue virus10.1038/s41598-020-78673-92045-2322https://doaj.org/article/08d400836ef3439bac794dd77fdc733c2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78673-9https://doaj.org/toc/2045-2322Abstract Bluetongue virus (BTV) epidemics are responsible for worldwide economic losses of up to US$ 3 billion. Understanding the global evolutionary epidemiology of BTV is critical in designing intervention programs. Here we employed phylodynamic models to quantify the evolutionary characteristics, spatiotemporal origins, and multi-host transmission dynamics of BTV across the globe. We inferred that goats are the ancestral hosts for BTV but are less likely to be important for cross-species transmission, sheep and cattle continue to be important for the transmission and maintenance of infection between other species. Our models pointed to China and India, countries with the highest population of goats, as the likely ancestral country for BTV emergence and dispersal worldwide over 1000 years ago. However, the increased diversification and dispersal of BTV coincided with the initiation of transcontinental livestock trade after the 1850s. Our analysis uncovered important epidemiological aspects of BTV that may guide future molecular surveillance of BTV.Moh A. AlkhamisCecilia Aguilar-VegaNicholas M. Fountain-JonesKai LinAndres M. PerezJosé M. Sánchez-VizcaínoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moh A. Alkhamis Cecilia Aguilar-Vega Nicholas M. Fountain-Jones Kai Lin Andres M. Perez José M. Sánchez-Vizcaíno Global emergence and evolutionary dynamics of bluetongue virus
description	Abstract Bluetongue virus (BTV) epidemics are responsible for worldwide economic losses of up to US$ 3 billion. Understanding the global evolutionary epidemiology of BTV is critical in designing intervention programs. Here we employed phylodynamic models to quantify the evolutionary characteristics, spatiotemporal origins, and multi-host transmission dynamics of BTV across the globe. We inferred that goats are the ancestral hosts for BTV but are less likely to be important for cross-species transmission, sheep and cattle continue to be important for the transmission and maintenance of infection between other species. Our models pointed to China and India, countries with the highest population of goats, as the likely ancestral country for BTV emergence and dispersal worldwide over 1000 years ago. However, the increased diversification and dispersal of BTV coincided with the initiation of transcontinental livestock trade after the 1850s. Our analysis uncovered important epidemiological aspects of BTV that may guide future molecular surveillance of BTV.
format	article
author	Moh A. Alkhamis Cecilia Aguilar-Vega Nicholas M. Fountain-Jones Kai Lin Andres M. Perez José M. Sánchez-Vizcaíno
author_facet	Moh A. Alkhamis Cecilia Aguilar-Vega Nicholas M. Fountain-Jones Kai Lin Andres M. Perez José M. Sánchez-Vizcaíno
author_sort	Moh A. Alkhamis
title	Global emergence and evolutionary dynamics of bluetongue virus
title_short	Global emergence and evolutionary dynamics of bluetongue virus
title_full	Global emergence and evolutionary dynamics of bluetongue virus
title_fullStr	Global emergence and evolutionary dynamics of bluetongue virus
title_full_unstemmed	Global emergence and evolutionary dynamics of bluetongue virus
title_sort	global emergence and evolutionary dynamics of bluetongue virus
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/08d400836ef3439bac794dd77fdc733c
work_keys_str_mv	AT mohaalkhamis globalemergenceandevolutionarydynamicsofbluetonguevirus AT ceciliaaguilarvega globalemergenceandevolutionarydynamicsofbluetonguevirus AT nicholasmfountainjones globalemergenceandevolutionarydynamicsofbluetonguevirus AT kailin globalemergenceandevolutionarydynamicsofbluetonguevirus AT andresmperez globalemergenceandevolutionarydynamicsofbluetonguevirus AT josemsanchezvizcaino globalemergenceandevolutionarydynamicsofbluetonguevirus
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Global emergence and evolutionary dynamics of bluetongue virus

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