Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke

The brain has the ability to reconstruct neural structures and functions to compensate for the brain lesions caused by stroke, although it is highly limited in primates including humans. Animal studies in which experimental lesions were induced in the brain have contributed to the current understand...

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Autor principal:	Noriyuki Higo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	brain lesions functional recovery macaque monkey marmoset pain plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/08d4de070e404827a627a43c3aaa8caa
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spelling	oai:doaj.org-article:08d4de070e404827a627a43c3aaa8caa2021-11-08T04:55:12ZNon-human Primate Models to Explore the Adaptive Mechanisms After Stroke1662-513710.3389/fnsys.2021.760311https://doaj.org/article/08d4de070e404827a627a43c3aaa8caa2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnsys.2021.760311/fullhttps://doaj.org/toc/1662-5137The brain has the ability to reconstruct neural structures and functions to compensate for the brain lesions caused by stroke, although it is highly limited in primates including humans. Animal studies in which experimental lesions were induced in the brain have contributed to the current understanding of the neural mechanisms underlying functional recovery. Here, I have highlighted recent advances in non-human primate models using primate species such as macaques and marmosets, most of which have been developed to study the mechanisms underlying the recovery of motor functions after stroke. Cortical lesion models have been used to investigate motor recovery after lesions to the cortical areas involved in movements of specific body parts. Models of a focal stroke at the posterior internal capsule have also been developed to bridge the gap between the knowledge obtained by cortical lesion models and the development of intervention strategies because the severity and outcome of motor deficits depend on the degree of lesions to the region. This review will also introduce other stroke models designed to study the plastic changes associated with development and recovery from cognitive and sensory impairments. Although further validation and careful interpretation are required, considering the differences between non-human primate brains and human brains, studies using brain-lesioned non-human primates offer promise for improving translational outcomes.Noriyuki HigoFrontiers Media S.A.articlebrain lesionsfunctional recoverymacaque monkeymarmosetpainplasticityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Systems Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain lesions functional recovery macaque monkey marmoset pain plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	brain lesions functional recovery macaque monkey marmoset pain plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Noriyuki Higo Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke
description	The brain has the ability to reconstruct neural structures and functions to compensate for the brain lesions caused by stroke, although it is highly limited in primates including humans. Animal studies in which experimental lesions were induced in the brain have contributed to the current understanding of the neural mechanisms underlying functional recovery. Here, I have highlighted recent advances in non-human primate models using primate species such as macaques and marmosets, most of which have been developed to study the mechanisms underlying the recovery of motor functions after stroke. Cortical lesion models have been used to investigate motor recovery after lesions to the cortical areas involved in movements of specific body parts. Models of a focal stroke at the posterior internal capsule have also been developed to bridge the gap between the knowledge obtained by cortical lesion models and the development of intervention strategies because the severity and outcome of motor deficits depend on the degree of lesions to the region. This review will also introduce other stroke models designed to study the plastic changes associated with development and recovery from cognitive and sensory impairments. Although further validation and careful interpretation are required, considering the differences between non-human primate brains and human brains, studies using brain-lesioned non-human primates offer promise for improving translational outcomes.
format	article
author	Noriyuki Higo
author_facet	Noriyuki Higo
author_sort	Noriyuki Higo
title	Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke
title_short	Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke
title_full	Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke
title_fullStr	Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke
title_full_unstemmed	Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke
title_sort	non-human primate models to explore the adaptive mechanisms after stroke
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/08d4de070e404827a627a43c3aaa8caa
work_keys_str_mv	AT noriyukihigo nonhumanprimatemodelstoexploretheadaptivemechanismsafterstroke
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Non-human Primate Models to Explore the Adaptive Mechanisms After Stroke

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