Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of...

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Autores principales:	Zuqiang Liu, Roshni Ravindranathan, Pawel Kalinski, Z. Sheng Guo, David L. Bartlett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08d52995317b46989e958cc19d18bdfc
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spelling	oai:doaj.org-article:08d52995317b46989e958cc19d18bdfc2021-12-02T17:06:11ZRational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy10.1038/ncomms147542041-1723https://doaj.org/article/08d52995317b46989e958cc19d18bdfc2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14754https://doaj.org/toc/2041-1723Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of activated T cells, and reducing exhausted T cells.Zuqiang LiuRoshni RavindranathanPawel KalinskiZ. Sheng GuoDavid L. BartlettNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zuqiang Liu Roshni Ravindranathan Pawel Kalinski Z. Sheng Guo David L. Bartlett Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
description	Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of activated T cells, and reducing exhausted T cells.
format	article
author	Zuqiang Liu Roshni Ravindranathan Pawel Kalinski Z. Sheng Guo David L. Bartlett
author_facet	Zuqiang Liu Roshni Ravindranathan Pawel Kalinski Z. Sheng Guo David L. Bartlett
author_sort	Zuqiang Liu
title	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_short	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_full	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_fullStr	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_full_unstemmed	Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy
title_sort	rational combination of oncolytic vaccinia virus and pd-l1 blockade works synergistically to enhance therapeutic efficacy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/08d52995317b46989e958cc19d18bdfc
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Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

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