Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?

Junshuai Xue,1,&ast; Delin Ma,2,&ast; Jianjun Jiang,1 Yang Liu1 1Department of General Surgery, Vascular Surgery, Shandong University Qilu Hospital, Jinan City, Shandong Province, People’s Republic of China; 2Department of General Surgery, Shandong University Qilu Hospital, Jinan City, Shand...

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Autores principales:	Xue J, Ma D, Jiang J, Liu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	venous thromboembolism immune/inflammation biomarker diagnosis prognosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/08d73b687aea4c188fbf192c422c7494
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spelling	oai:doaj.org-article:08d73b687aea4c188fbf192c422c74942021-12-02T17:37:26ZDiagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?1178-7031https://doaj.org/article/08d73b687aea4c188fbf192c422c74942021-10-01T00:00:00Zhttps://www.dovepress.com/diagnostic-and-prognostic-value-of-immuneinflammation-biomarkers-for-v-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Junshuai Xue,1,&ast; Delin Ma,2,&ast; Jianjun Jiang,1 Yang Liu1 1Department of General Surgery, Vascular Surgery, Shandong University Qilu Hospital, Jinan City, Shandong Province, People’s Republic of China; 2Department of General Surgery, Shandong University Qilu Hospital, Jinan City, Shandong Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yang LiuDepartment of General Surgery, Vascular Surgery, Shandong University Qilu Hospital, No. 107, Road Wen Hua Xi, Jinan City, Shandong Province, 250012, People’s Republic of ChinaTel +86 18560088317Email liuyang_sdu@126.comAbstract: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), has been an important cause of sudden in-hospital death. Studies have shown that the immune/inflammatory response plays an important role in the pathogenesis of vascular disease, with representative markers in the blood including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), systemic immune/inflammatory index (SII), etc. However, there is a variety of immune/inflammatory indicators. Moreover, most previous studies have been single-center investigations involving one or two indicators, with varying nature of cases, number of cases and study objectives, thereby making it difficult to reach consensus conclusions with good clinical guidelines. This article reviews the clinical value of immunoinflammatory indicators for VTE based on previous studies, including the diagnostic and prognostic capabilities. In conclusion, NLR provides promising predictive capability for the onset and prognosis of VTE and deserves extensive application in clinical practice. PLR also has certain diagnostic and prognostic value, but further studies are warranted to identify its reliability and stability. Monocytes, eosinophils and platelet-related indicators show some clinical association with VTE, although the predictive capabilities are mediocre. SII is of promising potential value for VTE and deserves further investigations. This review will provide new clues and valuable clinical guidance for the diagnosis and therapy of VTE.Keywords: venous thromboembolism, immune/inflammation biomarker, diagnosis, prognosisXue JMa DJiang JLiu YDove Medical Pressarticlevenous thromboembolismimmune/inflammation biomarkerdiagnosisprognosisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5059-5077 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	venous thromboembolism immune/inflammation biomarker diagnosis prognosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	venous thromboembolism immune/inflammation biomarker diagnosis prognosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Xue J Ma D Jiang J Liu Y Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?
description	Junshuai Xue,1,&ast; Delin Ma,2,&ast; Jianjun Jiang,1 Yang Liu1 1Department of General Surgery, Vascular Surgery, Shandong University Qilu Hospital, Jinan City, Shandong Province, People’s Republic of China; 2Department of General Surgery, Shandong University Qilu Hospital, Jinan City, Shandong Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yang LiuDepartment of General Surgery, Vascular Surgery, Shandong University Qilu Hospital, No. 107, Road Wen Hua Xi, Jinan City, Shandong Province, 250012, People’s Republic of ChinaTel +86 18560088317Email liuyang_sdu@126.comAbstract: Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), has been an important cause of sudden in-hospital death. Studies have shown that the immune/inflammatory response plays an important role in the pathogenesis of vascular disease, with representative markers in the blood including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), systemic immune/inflammatory index (SII), etc. However, there is a variety of immune/inflammatory indicators. Moreover, most previous studies have been single-center investigations involving one or two indicators, with varying nature of cases, number of cases and study objectives, thereby making it difficult to reach consensus conclusions with good clinical guidelines. This article reviews the clinical value of immunoinflammatory indicators for VTE based on previous studies, including the diagnostic and prognostic capabilities. In conclusion, NLR provides promising predictive capability for the onset and prognosis of VTE and deserves extensive application in clinical practice. PLR also has certain diagnostic and prognostic value, but further studies are warranted to identify its reliability and stability. Monocytes, eosinophils and platelet-related indicators show some clinical association with VTE, although the predictive capabilities are mediocre. SII is of promising potential value for VTE and deserves further investigations. This review will provide new clues and valuable clinical guidance for the diagnosis and therapy of VTE.Keywords: venous thromboembolism, immune/inflammation biomarker, diagnosis, prognosis
format	article
author	Xue J Ma D Jiang J Liu Y
author_facet	Xue J Ma D Jiang J Liu Y
author_sort	Xue J
title	Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?
title_short	Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?
title_full	Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?
title_fullStr	Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?
title_full_unstemmed	Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?
title_sort	diagnostic and prognostic value of immune/inflammation biomarkers for venous thromboembolism: is it reliable for clinical practice?
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/08d73b687aea4c188fbf192c422c7494
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Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?

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