Origin of the Functional Distinctiveness of NF-κB/p52

The transcription regulators of the NF-κB family have emerged as a critical factor affecting the function of various adult tissues. The NF-κB family transcription factors are homo- and heterodimers made up of five monomers (p50, p52, RelA, cRel and RelB). The family is distinguished by sequence homo...

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Autores principales:	Gourisankar Ghosh, Vivien Ya-Fan Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	NF-κB p52 transcriptional regulation DNA binding diseases Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/08d95e40f7be4ed0aae1650369e9ddc9
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id	oai:doaj.org-article:08d95e40f7be4ed0aae1650369e9ddc9
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spelling	oai:doaj.org-article:08d95e40f7be4ed0aae1650369e9ddc92021-11-30T14:06:41ZOrigin of the Functional Distinctiveness of NF-κB/p522296-634X10.3389/fcell.2021.764164https://doaj.org/article/08d95e40f7be4ed0aae1650369e9ddc92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.764164/fullhttps://doaj.org/toc/2296-634XThe transcription regulators of the NF-κB family have emerged as a critical factor affecting the function of various adult tissues. The NF-κB family transcription factors are homo- and heterodimers made up of five monomers (p50, p52, RelA, cRel and RelB). The family is distinguished by sequence homology in their DNA binding and dimerization domains, which enables them to bind similar DNA response elements and participate in similar biological programs through transcriptional activation and repression of hundreds of genes. Even though the family members are closely related in terms of sequence and function, they all display distinct activities. In this review, we discuss the sequence characteristics, protein and DNA interactions, and pathogenic involvement of one member of family, NF-κB/p52, relative to that of other members. We pinpoint the small sequence variations within the conserved region that are mostly responsible for its distinct functional properties.Gourisankar GhoshVivien Ya-Fan WangVivien Ya-Fan WangFrontiers Media S.A.articleNF-κBp52transcriptional regulationDNA bindingdiseasesBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NF-κB p52 transcriptional regulation DNA binding diseases Biology (General) QH301-705.5
spellingShingle	NF-κB p52 transcriptional regulation DNA binding diseases Biology (General) QH301-705.5 Gourisankar Ghosh Vivien Ya-Fan Wang Vivien Ya-Fan Wang Origin of the Functional Distinctiveness of NF-κB/p52
description	The transcription regulators of the NF-κB family have emerged as a critical factor affecting the function of various adult tissues. The NF-κB family transcription factors are homo- and heterodimers made up of five monomers (p50, p52, RelA, cRel and RelB). The family is distinguished by sequence homology in their DNA binding and dimerization domains, which enables them to bind similar DNA response elements and participate in similar biological programs through transcriptional activation and repression of hundreds of genes. Even though the family members are closely related in terms of sequence and function, they all display distinct activities. In this review, we discuss the sequence characteristics, protein and DNA interactions, and pathogenic involvement of one member of family, NF-κB/p52, relative to that of other members. We pinpoint the small sequence variations within the conserved region that are mostly responsible for its distinct functional properties.
format	article
author	Gourisankar Ghosh Vivien Ya-Fan Wang Vivien Ya-Fan Wang
author_facet	Gourisankar Ghosh Vivien Ya-Fan Wang Vivien Ya-Fan Wang
author_sort	Gourisankar Ghosh
title	Origin of the Functional Distinctiveness of NF-κB/p52
title_short	Origin of the Functional Distinctiveness of NF-κB/p52
title_full	Origin of the Functional Distinctiveness of NF-κB/p52
title_fullStr	Origin of the Functional Distinctiveness of NF-κB/p52
title_full_unstemmed	Origin of the Functional Distinctiveness of NF-κB/p52
title_sort	origin of the functional distinctiveness of nf-κb/p52
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/08d95e40f7be4ed0aae1650369e9ddc9
work_keys_str_mv	AT gourisankarghosh originofthefunctionaldistinctivenessofnfkbp52 AT vivienyafanwang originofthefunctionaldistinctivenessofnfkbp52 AT vivienyafanwang originofthefunctionaldistinctivenessofnfkbp52
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Origin of the Functional Distinctiveness of NF-κB/p52

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