Depression and pain: testing of serial multiple mediators

Tinakon Wongpakaran,1 Nahathai Wongpakaran,1 Sitthinant Tanchakvaranont,2 Putipong Bookkamana,3 Manee Pinyopornpanish,1 Kamonporn Wannarit,4 Sirina Satthapisit,5 Daochompu Nakawiro,6 Thanita Hiranyatheb,6 Kulvadee Thongpibul7 1Department of Psychiatry, Faculty of Medicine, Chiang Mai Unive...

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Autores principales:	Wongpakaran T, Wongpakaran N, Tanchakvaranont S, Bookkamana P, Pinyopornpanish M, Wannarit K, Satthapisit S, Nakawiro D, Hiranyatheb T, Thongpibul K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	depressive disorder mediator serial mediation multiple mediation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/08d99339031e49d088a3a6d4ff5503d3
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spelling	oai:doaj.org-article:08d99339031e49d088a3a6d4ff5503d32021-12-02T00:09:55ZDepression and pain: testing of serial multiple mediators1178-2021https://doaj.org/article/08d99339031e49d088a3a6d4ff5503d32016-07-01T00:00:00Zhttps://www.dovepress.com/depression-and-pain-testing-of-serial-multiple-mediators-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tinakon Wongpakaran,1 Nahathai Wongpakaran,1 Sitthinant Tanchakvaranont,2 Putipong Bookkamana,3 Manee Pinyopornpanish,1 Kamonporn Wannarit,4 Sirina Satthapisit,5 Daochompu Nakawiro,6 Thanita Hiranyatheb,6 Kulvadee Thongpibul7 1Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Kingdom of Thailand; 2Department of Psychiatry, Queen Savang Vadhana Memorial Hospital, Chonburi, Kingdom of Thailand; 3Department of Statistics, Faculty of Science, Chiang Mai University, Chiang Mai, Kingdom of Thailand; 4Department of Psychiatry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Kingdom of Thailand; 5Department of Psychiatry, Khon Kaen Regional Hospital, Khon Kaen, Kingdom of Thailand; 6Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Kingdom of Thailand; 7Department of Psychology, Faculty of Humanities, Chiang Mai University, Chiang Mai, Kingdom of Thailand Purpose: Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders.Participants and methods: An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36), the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed.Results: Perceived stress, self-sacrificing interpersonal style, and cognitive function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator.Conclusion: Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future research, both in terms of testing the model and in clinical application. Keywords: depressive disorder, mediator, serial mediation, multiple mediationWongpakaran TWongpakaran NTanchakvaranont SBookkamana PPinyopornpanish MWannarit KSatthapisit SNakawiro DHiranyatheb TThongpibul KDove Medical Pressarticledepressive disordermediatorserial mediationmultiple mediationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1849-1860 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	depressive disorder mediator serial mediation multiple mediation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depressive disorder mediator serial mediation multiple mediation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wongpakaran T Wongpakaran N Tanchakvaranont S Bookkamana P Pinyopornpanish M Wannarit K Satthapisit S Nakawiro D Hiranyatheb T Thongpibul K Depression and pain: testing of serial multiple mediators
description	Tinakon Wongpakaran,1 Nahathai Wongpakaran,1 Sitthinant Tanchakvaranont,2 Putipong Bookkamana,3 Manee Pinyopornpanish,1 Kamonporn Wannarit,4 Sirina Satthapisit,5 Daochompu Nakawiro,6 Thanita Hiranyatheb,6 Kulvadee Thongpibul7 1Department of Psychiatry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Kingdom of Thailand; 2Department of Psychiatry, Queen Savang Vadhana Memorial Hospital, Chonburi, Kingdom of Thailand; 3Department of Statistics, Faculty of Science, Chiang Mai University, Chiang Mai, Kingdom of Thailand; 4Department of Psychiatry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Kingdom of Thailand; 5Department of Psychiatry, Khon Kaen Regional Hospital, Khon Kaen, Kingdom of Thailand; 6Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Kingdom of Thailand; 7Department of Psychology, Faculty of Humanities, Chiang Mai University, Chiang Mai, Kingdom of Thailand Purpose: Despite the fact that pain is related to depression, few studies have been conducted to investigate the variables that mediate between the two conditions. In this study, the authors explored the following mediators: cognitive function, self-sacrificing interpersonal problems, and perception of stress, and the effects they had on pain symptoms among patients with depressive disorders.Participants and methods: An analysis was performed on the data of 346 participants with unipolar depressive disorders. The 17-item Hamilton Depression Rating Scale, Mini-Mental State Examination, the pain subscale of the health-related quality of life (SF-36), the self-sacrificing subscale of the Inventory of Interpersonal Problems, and the Perceived Stress Scale were used. Parallel multiple mediator and serial multiple mediator models were used. An alternative model regarding the effect of self-sacrificing on pain was also proposed.Results: Perceived stress, self-sacrificing interpersonal style, and cognitive function were found to significantly mediate the relationship between depression and pain, while controlling for demographic variables. The total effect of depression on pain was significant. This model, with an additional three mediators, accounted for 15% of the explained variance in pain compared to 9% without mediators. For the alternative model, after controlling for the mediators, a nonsignificant total direct effect level of self-sacrificing was found, suggesting that the effect of self-sacrificing on pain was based only on an indirect effect and that perceived stress was found to be the strongest mediator.Conclusion: Serial mediation may help us to see how depression and pain are linked and what the fundamental mediators are in the chain. No significant, indirect effect of self-sacrificing on pain was observed, if perceived stress was not part of the depression and/or cognitive function mediational chain. The results shown here have implications for future research, both in terms of testing the model and in clinical application. Keywords: depressive disorder, mediator, serial mediation, multiple mediation
format	article
author	Wongpakaran T Wongpakaran N Tanchakvaranont S Bookkamana P Pinyopornpanish M Wannarit K Satthapisit S Nakawiro D Hiranyatheb T Thongpibul K
author_facet	Wongpakaran T Wongpakaran N Tanchakvaranont S Bookkamana P Pinyopornpanish M Wannarit K Satthapisit S Nakawiro D Hiranyatheb T Thongpibul K
author_sort	Wongpakaran T
title	Depression and pain: testing of serial multiple mediators
title_short	Depression and pain: testing of serial multiple mediators
title_full	Depression and pain: testing of serial multiple mediators
title_fullStr	Depression and pain: testing of serial multiple mediators
title_full_unstemmed	Depression and pain: testing of serial multiple mediators
title_sort	depression and pain: testing of serial multiple mediators
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/08d99339031e49d088a3a6d4ff5503d3
work_keys_str_mv	AT wongpakarant depressionandpaintestingofserialmultiplemediators AT wongpakarann depressionandpaintestingofserialmultiplemediators AT tanchakvaranonts depressionandpaintestingofserialmultiplemediators AT bookkamanap depressionandpaintestingofserialmultiplemediators AT pinyopornpanishm depressionandpaintestingofserialmultiplemediators AT wannaritk depressionandpaintestingofserialmultiplemediators AT satthapisits depressionandpaintestingofserialmultiplemediators AT nakawirod depressionandpaintestingofserialmultiplemediators AT hiranyathebt depressionandpaintestingofserialmultiplemediators AT thongpibulk depressionandpaintestingofserialmultiplemediators
_version_	1718403907004137472

Depression and pain: testing of serial multiple mediators

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