TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis

TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis

Therapeutic options for triple-negative breast cancer (TNBC) metastasis are limited. Here they show nanoparticle-mediated delivery of TAK1 inhibitor 5Z-7-Oxozeaenol to inhibit TNBC lung metastasis in mice, and that TAK1 might promote TNBC cell adaptation in lung microenvironment by positive feedback...

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Autores principales: Oihana Iriondo, Yarong Liu, Grace Lee, Mostafa Elhodaky, Christian Jimenez, Lin Li, Julie Lang, Pin Wang, Min Yu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/08d9a12288624aea87b1190c95b1352d
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spelling oai:doaj.org-article:08d9a12288624aea87b1190c95b1352d2021-12-02T15:33:57ZTAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis10.1038/s41467-018-04460-w2041-1723https://doaj.org/article/08d9a12288624aea87b1190c95b1352d2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04460-whttps://doaj.org/toc/2041-1723Therapeutic options for triple-negative breast cancer (TNBC) metastasis are limited. Here they show nanoparticle-mediated delivery of TAK1 inhibitor 5Z-7-Oxozeaenol to inhibit TNBC lung metastasis in mice, and that TAK1 might promote TNBC cell adaptation in lung microenvironment by positive feedback mediated by P38 signaling.Oihana IriondoYarong LiuGrace LeeMostafa ElhodakyChristian JimenezLin LiJulie LangPin WangMin YuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Oihana Iriondo
Yarong Liu
Grace Lee
Mostafa Elhodaky
Christian Jimenez
Lin Li
Julie Lang
Pin Wang
Min Yu
TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis
description Therapeutic options for triple-negative breast cancer (TNBC) metastasis are limited. Here they show nanoparticle-mediated delivery of TAK1 inhibitor 5Z-7-Oxozeaenol to inhibit TNBC lung metastasis in mice, and that TAK1 might promote TNBC cell adaptation in lung microenvironment by positive feedback mediated by P38 signaling.
format article
author Oihana Iriondo
Yarong Liu
Grace Lee
Mostafa Elhodaky
Christian Jimenez
Lin Li
Julie Lang
Pin Wang
Min Yu
author_facet Oihana Iriondo
Yarong Liu
Grace Lee
Mostafa Elhodaky
Christian Jimenez
Lin Li
Julie Lang
Pin Wang
Min Yu
author_sort Oihana Iriondo
title TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis
title_short TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis
title_full TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis
title_fullStr TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis
title_full_unstemmed TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis
title_sort tak1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/08d9a12288624aea87b1190c95b1352d
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