Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

Autophagy declines with age, yet it is unclear if restoration of autophagy extends lifespan. Here, the authors demonstrate in murine models that the inhibition of Atg5 induces ageing phenotypes and reduces lifespan, whilst autophagy restoration partially reverses these phenotypes with accelerated tu...

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Autores principales:	Liam D. Cassidy, Andrew R. J. Young, Christopher N. J. Young, Elizabeth J. Soilleux, Edward Fielder, Bettina M. Weigand, Anthony Lagnado, Rebecca Brais, Nicholas T. Ktistakis, Kimberley A. Wiggins, Katerina Pyrillou, Murray C. H. Clarke, Diana Jurk, Joao F. Passos, Masashi Narita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08d9c43fad6f4fa996ca4382c883b9dc
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spelling	oai:doaj.org-article:08d9c43fad6f4fa996ca4382c883b9dc2021-12-02T15:39:06ZTemporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk10.1038/s41467-019-14187-x2041-1723https://doaj.org/article/08d9c43fad6f4fa996ca4382c883b9dc2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14187-xhttps://doaj.org/toc/2041-1723Autophagy declines with age, yet it is unclear if restoration of autophagy extends lifespan. Here, the authors demonstrate in murine models that the inhibition of Atg5 induces ageing phenotypes and reduces lifespan, whilst autophagy restoration partially reverses these phenotypes with accelerated tumorigenesis.Liam D. CassidyAndrew R. J. YoungChristopher N. J. YoungElizabeth J. SoilleuxEdward FielderBettina M. WeigandAnthony LagnadoRebecca BraisNicholas T. KtistakisKimberley A. WigginsKaterina PyrillouMurray C. H. ClarkeDiana JurkJoao F. PassosMasashi NaritaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liam D. Cassidy Andrew R. J. Young Christopher N. J. Young Elizabeth J. Soilleux Edward Fielder Bettina M. Weigand Anthony Lagnado Rebecca Brais Nicholas T. Ktistakis Kimberley A. Wiggins Katerina Pyrillou Murray C. H. Clarke Diana Jurk Joao F. Passos Masashi Narita Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
description	Autophagy declines with age, yet it is unclear if restoration of autophagy extends lifespan. Here, the authors demonstrate in murine models that the inhibition of Atg5 induces ageing phenotypes and reduces lifespan, whilst autophagy restoration partially reverses these phenotypes with accelerated tumorigenesis.
format	article
author	Liam D. Cassidy Andrew R. J. Young Christopher N. J. Young Elizabeth J. Soilleux Edward Fielder Bettina M. Weigand Anthony Lagnado Rebecca Brais Nicholas T. Ktistakis Kimberley A. Wiggins Katerina Pyrillou Murray C. H. Clarke Diana Jurk Joao F. Passos Masashi Narita
author_facet	Liam D. Cassidy Andrew R. J. Young Christopher N. J. Young Elizabeth J. Soilleux Edward Fielder Bettina M. Weigand Anthony Lagnado Rebecca Brais Nicholas T. Ktistakis Kimberley A. Wiggins Katerina Pyrillou Murray C. H. Clarke Diana Jurk Joao F. Passos Masashi Narita
author_sort	Liam D. Cassidy
title	Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
title_short	Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
title_full	Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
title_fullStr	Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
title_full_unstemmed	Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
title_sort	temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/08d9c43fad6f4fa996ca4382c883b9dc
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Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

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