Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder

Abstract Impulsive behaviours are common symptoms of attention-deficit hyperactivity disorder (ADHD). Although previous studies have suggested functional models of impulsive behaviour, a full explanation of impulsivity in ADHD remains elusive. To investigate the detailed mechanisms behind impulsive...

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Autores principales:	Saori C. Tanaka, Noriaki Yahata, Ayako Todokoro, Yuki Kawakubo, Yukiko Kano, Yukika Nishimura, Ayaka Ishii-Takahashi, Fumio Ohtake, Kiyoto Kasai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08dcff9774934d0ba03116b6c547becc
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spelling	oai:doaj.org-article:08dcff9774934d0ba03116b6c547becc2021-12-02T16:08:25ZPreliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder10.1038/s41598-018-24944-52045-2322https://doaj.org/article/08dcff9774934d0ba03116b6c547becc2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24944-5https://doaj.org/toc/2045-2322Abstract Impulsive behaviours are common symptoms of attention-deficit hyperactivity disorder (ADHD). Although previous studies have suggested functional models of impulsive behaviour, a full explanation of impulsivity in ADHD remains elusive. To investigate the detailed mechanisms behind impulsive behaviour in ADHD, we applied an economic intertemporal choice task involving gains and losses to adults with ADHD and healthy controls and measured brain activity by functional magnetic resonance imaging. In the intertemporal choice of future gains, we observed no behavioural or neural difference between the two groups. In the intertemporal choice of future losses, adults with ADHD exhibited higher discount rates than the control participants. Furthermore, a comparison of brain activity representing the sensitivity of future loss in the two groups revealed significantly lower activity in the striatum and higher activity in the amygdala in adults with ADHD than in controls. Our preliminary findings suggest that an altered size sensitivity to future loss is involved in apparent impulsive choice behaviour in adults with ADHD and shed light on the multifaceted impulsivity underlying ADHD.Saori C. TanakaNoriaki YahataAyako TodokoroYuki KawakuboYukiko KanoYukika NishimuraAyaka Ishii-TakahashiFumio OhtakeKiyoto KasaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saori C. Tanaka Noriaki Yahata Ayako Todokoro Yuki Kawakubo Yukiko Kano Yukika Nishimura Ayaka Ishii-Takahashi Fumio Ohtake Kiyoto Kasai Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder
description	Abstract Impulsive behaviours are common symptoms of attention-deficit hyperactivity disorder (ADHD). Although previous studies have suggested functional models of impulsive behaviour, a full explanation of impulsivity in ADHD remains elusive. To investigate the detailed mechanisms behind impulsive behaviour in ADHD, we applied an economic intertemporal choice task involving gains and losses to adults with ADHD and healthy controls and measured brain activity by functional magnetic resonance imaging. In the intertemporal choice of future gains, we observed no behavioural or neural difference between the two groups. In the intertemporal choice of future losses, adults with ADHD exhibited higher discount rates than the control participants. Furthermore, a comparison of brain activity representing the sensitivity of future loss in the two groups revealed significantly lower activity in the striatum and higher activity in the amygdala in adults with ADHD than in controls. Our preliminary findings suggest that an altered size sensitivity to future loss is involved in apparent impulsive choice behaviour in adults with ADHD and shed light on the multifaceted impulsivity underlying ADHD.
format	article
author	Saori C. Tanaka Noriaki Yahata Ayako Todokoro Yuki Kawakubo Yukiko Kano Yukika Nishimura Ayaka Ishii-Takahashi Fumio Ohtake Kiyoto Kasai
author_facet	Saori C. Tanaka Noriaki Yahata Ayako Todokoro Yuki Kawakubo Yukiko Kano Yukika Nishimura Ayaka Ishii-Takahashi Fumio Ohtake Kiyoto Kasai
author_sort	Saori C. Tanaka
title	Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder
title_short	Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder
title_full	Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder
title_fullStr	Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder
title_full_unstemmed	Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder
title_sort	preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/08dcff9774934d0ba03116b6c547becc
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Preliminary evidence of altered neural response during intertemporal choice of losses in adult attention-deficit hyperactivity disorder

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