Organ-specific pathomorphological changes during COVID-19

COVID-19 is an acute respiratory infection caused by SARS-CoV-2 coronavirus causing pneumonia, lesions in the cardiovascular system and other organs, high mortality risk, especially in geriatric patients. Due to the great relevance, this study was aimed at describing the case of severe COVID-19 with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. V. Vorobeva, A. V. Lastochkin
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2020
Materias:	covid-19 coronary heart disease arterial hypertension pneumonia Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/08e2b1420ac247699ec09ce5b50e9e84
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:08e2b1420ac247699ec09ce5b50e9e84
record_format	dspace
spelling	oai:doaj.org-article:08e2b1420ac247699ec09ce5b50e9e842021-11-22T07:09:54ZOrgan-specific pathomorphological changes during COVID-192220-76192313-739810.15789/2220-7619-PCI-1483https://doaj.org/article/08e2b1420ac247699ec09ce5b50e9e842020-08-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1483https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398COVID-19 is an acute respiratory infection caused by SARS-CoV-2 coronavirus causing pneumonia, lesions in the cardiovascular system and other organs, high mortality risk, especially in geriatric patients. Due to the great relevance, this study was aimed at describing the case of severe COVID-19 with development of multiple organ failure. Materials and methods. Available accompanying medical documentation (outpatient charts, medical history) was analyzed. Clinical and morphological analysis was carried out by providing description of macro- and micropreparations; histological methods (hematoxylin and eosin staining, Lee reaction) were used. Results. Female patient K.G., 69 years old, was hospitalized to the therapeutic department diagnosed with coronary heart disease. Acute coronary syndrome with ST segment elevation was made on 04/20/2020. A competing diagnosis: severe community-acquired bilateral multi-segmental pneumonia. The patient’s condition was aggravated wile applying therapy followed by biological death occurred. An autopsy revealed bilateral subtotal hemorrhagic pneumonia. Macroscopic lung examination demonstrated “lungs filled with red fluid”. In the brain — perivascular and pericellular edema, hyalinosis, blood stasis and sludge, marked dystrophic and necrotic neuronal changes. Cardiomyocyte fragmentation, areas of perivascular sclerosis with inflammatory infiltrates as well as erythrocytic sludge are found in the heart and blood vessels, respectively. A weak positive reaction according to Lee method was observed. Such clinical and morphological case demonstrates along with lung damage involvement of the heart resulting in acute coronary syndrome (morphologically manifested by ischemic myocardial dystrophy) and the brain. Thus, premorbid background in elderly patients results in developing acute pulmonary heart failure, pulmonary and cerebral edema.O. V. VorobevaA. V. LastochkinSankt-Peterburg : NIIÈM imeni Pasteraarticlecovid-19coronary heart diseasearterial hypertensionpneumoniaInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 10, Iss 3, Pp 587-590 (2020)
institution	DOAJ
collection	DOAJ
language	RU
topic	covid-19 coronary heart disease arterial hypertension pneumonia Infectious and parasitic diseases RC109-216
spellingShingle	covid-19 coronary heart disease arterial hypertension pneumonia Infectious and parasitic diseases RC109-216 O. V. Vorobeva A. V. Lastochkin Organ-specific pathomorphological changes during COVID-19
description	COVID-19 is an acute respiratory infection caused by SARS-CoV-2 coronavirus causing pneumonia, lesions in the cardiovascular system and other organs, high mortality risk, especially in geriatric patients. Due to the great relevance, this study was aimed at describing the case of severe COVID-19 with development of multiple organ failure. Materials and methods. Available accompanying medical documentation (outpatient charts, medical history) was analyzed. Clinical and morphological analysis was carried out by providing description of macro- and micropreparations; histological methods (hematoxylin and eosin staining, Lee reaction) were used. Results. Female patient K.G., 69 years old, was hospitalized to the therapeutic department diagnosed with coronary heart disease. Acute coronary syndrome with ST segment elevation was made on 04/20/2020. A competing diagnosis: severe community-acquired bilateral multi-segmental pneumonia. The patient’s condition was aggravated wile applying therapy followed by biological death occurred. An autopsy revealed bilateral subtotal hemorrhagic pneumonia. Macroscopic lung examination demonstrated “lungs filled with red fluid”. In the brain — perivascular and pericellular edema, hyalinosis, blood stasis and sludge, marked dystrophic and necrotic neuronal changes. Cardiomyocyte fragmentation, areas of perivascular sclerosis with inflammatory infiltrates as well as erythrocytic sludge are found in the heart and blood vessels, respectively. A weak positive reaction according to Lee method was observed. Such clinical and morphological case demonstrates along with lung damage involvement of the heart resulting in acute coronary syndrome (morphologically manifested by ischemic myocardial dystrophy) and the brain. Thus, premorbid background in elderly patients results in developing acute pulmonary heart failure, pulmonary and cerebral edema.
format	article
author	O. V. Vorobeva A. V. Lastochkin
author_facet	O. V. Vorobeva A. V. Lastochkin
author_sort	O. V. Vorobeva
title	Organ-specific pathomorphological changes during COVID-19
title_short	Organ-specific pathomorphological changes during COVID-19
title_full	Organ-specific pathomorphological changes during COVID-19
title_fullStr	Organ-specific pathomorphological changes during COVID-19
title_full_unstemmed	Organ-specific pathomorphological changes during COVID-19
title_sort	organ-specific pathomorphological changes during covid-19
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2020
url	https://doaj.org/article/08e2b1420ac247699ec09ce5b50e9e84
work_keys_str_mv	AT ovvorobeva organspecificpathomorphologicalchangesduringcovid19 AT avlastochkin organspecificpathomorphologicalchangesduringcovid19
_version_	1718417897444868096

Organ-specific pathomorphological changes during COVID-19

Ejemplares similares