First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines

ABSTRACT Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target...

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Autores principales:	Francesco Borriello, Simon D. van Haren, Ofer Levy
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	adjuvants immunization meeting report precision vaccines systems vaccinology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/08e3624228af4bf1825ba34e635d7fa8
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spelling	oai:doaj.org-article:08e3624228af4bf1825ba34e635d7fa82021-11-15T15:25:51ZFirst International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines10.1128/mSphere.00214-182379-5042https://doaj.org/article/08e3624228af4bf1825ba34e635d7fa82018-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00214-18https://doaj.org/toc/2379-5042ABSTRACT Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pathogens due to intrinsic features of the microorganism, such as genetic/antigenic variability between strains, and our limited understanding of the variables that regulate vaccine responsiveness, including age- and sex-specific differences. Moreover, the traditional approach to vaccine development is often empirical, relying on inactivation of microorganisms or purification of their components, which are usually less immunogenic than the whole microorganism from which they derive. This approach has yielded multiple important vaccines but has failed to consistently generate vaccines that are sufficiently immunogenic in populations with limited immune responsiveness such as newborns and elderly individuals. In an effort to trigger impactful collaborations, a community of scientists gathered in Boston in the United States for the first biennial International Precision Vaccines Conference, sponsored by the Boston Children’s Hospital Precision Vaccines Program, to discuss innovation in vaccinology. Recent advancements in the field of systems biology that can identify vaccine immunogenicity biomarkers for target populations, in human in vitro models, and in novel adjuvant and formulation strategies offer unprecedented opportunities to dissect the human immune response to vaccines and inform dramatic improvements in vaccine efficacy. These approaches are poised to have a major scientific and translational impact in vaccinology.Francesco BorrielloSimon D. van HarenOfer LevyAmerican Society for Microbiologyarticleadjuvantsimmunizationmeeting reportprecision vaccinessystems vaccinologyMicrobiologyQR1-502ENmSphere, Vol 3, Iss 4 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	adjuvants immunization meeting report precision vaccines systems vaccinology Microbiology QR1-502
spellingShingle	adjuvants immunization meeting report precision vaccines systems vaccinology Microbiology QR1-502 Francesco Borriello Simon D. van Haren Ofer Levy First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
description	ABSTRACT Vaccines represent a remarkable success in the history of medicine since they have prevented and, in some instances, eradicated a range of infectious diseases. However, for many existing vaccines, immunogenicity is limited, requiring multiple booster doses, and we are still unable to target many pathogens due to intrinsic features of the microorganism, such as genetic/antigenic variability between strains, and our limited understanding of the variables that regulate vaccine responsiveness, including age- and sex-specific differences. Moreover, the traditional approach to vaccine development is often empirical, relying on inactivation of microorganisms or purification of their components, which are usually less immunogenic than the whole microorganism from which they derive. This approach has yielded multiple important vaccines but has failed to consistently generate vaccines that are sufficiently immunogenic in populations with limited immune responsiveness such as newborns and elderly individuals. In an effort to trigger impactful collaborations, a community of scientists gathered in Boston in the United States for the first biennial International Precision Vaccines Conference, sponsored by the Boston Children’s Hospital Precision Vaccines Program, to discuss innovation in vaccinology. Recent advancements in the field of systems biology that can identify vaccine immunogenicity biomarkers for target populations, in human in vitro models, and in novel adjuvant and formulation strategies offer unprecedented opportunities to dissect the human immune response to vaccines and inform dramatic improvements in vaccine efficacy. These approaches are poised to have a major scientific and translational impact in vaccinology.
format	article
author	Francesco Borriello Simon D. van Haren Ofer Levy
author_facet	Francesco Borriello Simon D. van Haren Ofer Levy
author_sort	Francesco Borriello
title	First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_short	First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_full	First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_fullStr	First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_full_unstemmed	First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines
title_sort	first international precision vaccines conference: multidisciplinary approaches to next-generation vaccines
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/08e3624228af4bf1825ba34e635d7fa8
work_keys_str_mv	AT francescoborriello firstinternationalprecisionvaccinesconferencemultidisciplinaryapproachestonextgenerationvaccines AT simondvanharen firstinternationalprecisionvaccinesconferencemultidisciplinaryapproachestonextgenerationvaccines AT oferlevy firstinternationalprecisionvaccinesconferencemultidisciplinaryapproachestonextgenerationvaccines
_version_	1718427929613959168

First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines

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