Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.

The deposition of β-amyloid (Aβ) into senile plaques and the impairment of somatostatin-mediated neurotransmission are key pathological events in the onset of Alzheimer's disease (AD). Insulin-degrading-enzyme (IDE) is one of the main extracellular protease targeting Aβ, and thus it represents...

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Autores principales:	Grazia Tundo, Chiara Ciaccio, Diego Sbardella, Mariaserena Boraso, Barbara Viviani, Massimiliano Coletta, Stefano Marini
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08e5ea94cdaf4e62b3cda27424c76a2c
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spelling	oai:doaj.org-article:08e5ea94cdaf4e62b3cda27424c76a2c2021-11-18T07:23:23ZSomatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.1932-620310.1371/journal.pone.0034376https://doaj.org/article/08e5ea94cdaf4e62b3cda27424c76a2c2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22509294/?tool=EBIhttps://doaj.org/toc/1932-6203The deposition of β-amyloid (Aβ) into senile plaques and the impairment of somatostatin-mediated neurotransmission are key pathological events in the onset of Alzheimer's disease (AD). Insulin-degrading-enzyme (IDE) is one of the main extracellular protease targeting Aβ, and thus it represents an interesting pharmacological target for AD therapy. We show that the active form of somatostatin-14 regulates IDE activity by affecting its expression and secretion in microglia cells. A similar effect can also be observed when adding octreotide. Following a previous observation where somatostatin directly interacts with IDE, here we demonstrate that somatostatin regulates Aβ catabolism by modulating IDE proteolytic activity in IDE gene-silencing experiments. As a whole, these data indicate the relevant role played by somatostatin and, potentially, by analogue octreotide, in preventing Aβ accumulation by partially restoring IDE activity.Grazia TundoChiara CiaccioDiego SbardellaMariaserena BorasoBarbara VivianiMassimiliano ColettaStefano MariniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34376 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Grazia Tundo Chiara Ciaccio Diego Sbardella Mariaserena Boraso Barbara Viviani Massimiliano Coletta Stefano Marini Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
description	The deposition of β-amyloid (Aβ) into senile plaques and the impairment of somatostatin-mediated neurotransmission are key pathological events in the onset of Alzheimer's disease (AD). Insulin-degrading-enzyme (IDE) is one of the main extracellular protease targeting Aβ, and thus it represents an interesting pharmacological target for AD therapy. We show that the active form of somatostatin-14 regulates IDE activity by affecting its expression and secretion in microglia cells. A similar effect can also be observed when adding octreotide. Following a previous observation where somatostatin directly interacts with IDE, here we demonstrate that somatostatin regulates Aβ catabolism by modulating IDE proteolytic activity in IDE gene-silencing experiments. As a whole, these data indicate the relevant role played by somatostatin and, potentially, by analogue octreotide, in preventing Aβ accumulation by partially restoring IDE activity.
format	article
author	Grazia Tundo Chiara Ciaccio Diego Sbardella Mariaserena Boraso Barbara Viviani Massimiliano Coletta Stefano Marini
author_facet	Grazia Tundo Chiara Ciaccio Diego Sbardella Mariaserena Boraso Barbara Viviani Massimiliano Coletta Stefano Marini
author_sort	Grazia Tundo
title	Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
title_short	Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
title_full	Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
title_fullStr	Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
title_full_unstemmed	Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.
title_sort	somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in ad.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/08e5ea94cdaf4e62b3cda27424c76a2c
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Somatostatin modulates insulin-degrading-enzyme metabolism: implications for the regulation of microglia activity in AD.

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