The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a

Abstract MicroRNAs play an important role in the regulation of T cell development, activation, and differentiation. One of the most abundant microRNAs in lymphocytes is miR-181a, which controls T cell receptor (TCR) activation thresholds in thymic selection as well as in peripheral T cell responses....

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Autores principales: Zhongde Ye, Timothy M. Gould, Huimin Zhang, Jun Jin, Cornelia M. Weyand, Jörg J. Goronzy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/08e6f57628f742cbbf6c188b84d4f6a7
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