Cellular metabolism constrains innate immune responses in early human ontogeny

Little is known about developmental set points of immune responses, especially in humans. Here the authors show that the metabolic state of monocytes isolated from prematurely born infants underlies attenuated responsiveness to fungal infection via selective control of protein translation.

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Detalles Bibliográficos
Autores principales:	Bernard Kan, Christina Michalski, Helen Fu, Hilda H. T. Au, Kelsey Lee, Elizabeth A. Marchant, Maye F. Cheng, Emily Anderson-Baucum, Michal Aharoni-Simon, Peter Tilley, Raghavendra G. Mirmira, Colin J. Ross, Dan S. Luciani, Eric Jan, Pascal M. Lavoie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08e85291ad4f44b1ab3852a20f070f42
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spelling	oai:doaj.org-article:08e85291ad4f44b1ab3852a20f070f422021-12-02T14:40:02ZCellular metabolism constrains innate immune responses in early human ontogeny10.1038/s41467-018-07215-92041-1723https://doaj.org/article/08e85291ad4f44b1ab3852a20f070f422018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07215-9https://doaj.org/toc/2041-1723Little is known about developmental set points of immune responses, especially in humans. Here the authors show that the metabolic state of monocytes isolated from prematurely born infants underlies attenuated responsiveness to fungal infection via selective control of protein translation.Bernard KanChristina MichalskiHelen FuHilda H. T. AuKelsey LeeElizabeth A. MarchantMaye F. ChengEmily Anderson-BaucumMichal Aharoni-SimonPeter TilleyRaghavendra G. MirmiraColin J. RossDan S. LucianiEric JanPascal M. LavoieNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernard Kan Christina Michalski Helen Fu Hilda H. T. Au Kelsey Lee Elizabeth A. Marchant Maye F. Cheng Emily Anderson-Baucum Michal Aharoni-Simon Peter Tilley Raghavendra G. Mirmira Colin J. Ross Dan S. Luciani Eric Jan Pascal M. Lavoie Cellular metabolism constrains innate immune responses in early human ontogeny
description	Little is known about developmental set points of immune responses, especially in humans. Here the authors show that the metabolic state of monocytes isolated from prematurely born infants underlies attenuated responsiveness to fungal infection via selective control of protein translation.
format	article
author	Bernard Kan Christina Michalski Helen Fu Hilda H. T. Au Kelsey Lee Elizabeth A. Marchant Maye F. Cheng Emily Anderson-Baucum Michal Aharoni-Simon Peter Tilley Raghavendra G. Mirmira Colin J. Ross Dan S. Luciani Eric Jan Pascal M. Lavoie
author_facet	Bernard Kan Christina Michalski Helen Fu Hilda H. T. Au Kelsey Lee Elizabeth A. Marchant Maye F. Cheng Emily Anderson-Baucum Michal Aharoni-Simon Peter Tilley Raghavendra G. Mirmira Colin J. Ross Dan S. Luciani Eric Jan Pascal M. Lavoie
author_sort	Bernard Kan
title	Cellular metabolism constrains innate immune responses in early human ontogeny
title_short	Cellular metabolism constrains innate immune responses in early human ontogeny
title_full	Cellular metabolism constrains innate immune responses in early human ontogeny
title_fullStr	Cellular metabolism constrains innate immune responses in early human ontogeny
title_full_unstemmed	Cellular metabolism constrains innate immune responses in early human ontogeny
title_sort	cellular metabolism constrains innate immune responses in early human ontogeny
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/08e85291ad4f44b1ab3852a20f070f42
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Cellular metabolism constrains innate immune responses in early human ontogeny

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