A gene regulatory network to control EMT programs in development and disease

EMT is a developmental process that is aberrantly activated in metastasizing cancer cells, but how multiple transcription factors regulate EMT is unclear. Here, the authors uncover a gene regulatory network between Prrx1 and Snail1 that selects EMT mode in developing vertebrates and cancer cells.

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Autores principales:	Hassan Fazilaty, Luciano Rago, Khalil Kass Youssef, Oscar H. Ocaña, Francisco Garcia-Asencio, Aida Arcas, Juan Galceran, M. Angela Nieto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08e953ed2ee54167890462b34ebbf788
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spelling	oai:doaj.org-article:08e953ed2ee54167890462b34ebbf7882021-12-02T15:35:40ZA gene regulatory network to control EMT programs in development and disease10.1038/s41467-019-13091-82041-1723https://doaj.org/article/08e953ed2ee54167890462b34ebbf7882019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13091-8https://doaj.org/toc/2041-1723EMT is a developmental process that is aberrantly activated in metastasizing cancer cells, but how multiple transcription factors regulate EMT is unclear. Here, the authors uncover a gene regulatory network between Prrx1 and Snail1 that selects EMT mode in developing vertebrates and cancer cells.Hassan FazilatyLuciano RagoKhalil Kass YoussefOscar H. OcañaFrancisco Garcia-AsencioAida ArcasJuan GalceranM. Angela NietoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hassan Fazilaty Luciano Rago Khalil Kass Youssef Oscar H. Ocaña Francisco Garcia-Asencio Aida Arcas Juan Galceran M. Angela Nieto A gene regulatory network to control EMT programs in development and disease
description	EMT is a developmental process that is aberrantly activated in metastasizing cancer cells, but how multiple transcription factors regulate EMT is unclear. Here, the authors uncover a gene regulatory network between Prrx1 and Snail1 that selects EMT mode in developing vertebrates and cancer cells.
format	article
author	Hassan Fazilaty Luciano Rago Khalil Kass Youssef Oscar H. Ocaña Francisco Garcia-Asencio Aida Arcas Juan Galceran M. Angela Nieto
author_facet	Hassan Fazilaty Luciano Rago Khalil Kass Youssef Oscar H. Ocaña Francisco Garcia-Asencio Aida Arcas Juan Galceran M. Angela Nieto
author_sort	Hassan Fazilaty
title	A gene regulatory network to control EMT programs in development and disease
title_short	A gene regulatory network to control EMT programs in development and disease
title_full	A gene regulatory network to control EMT programs in development and disease
title_fullStr	A gene regulatory network to control EMT programs in development and disease
title_full_unstemmed	A gene regulatory network to control EMT programs in development and disease
title_sort	gene regulatory network to control emt programs in development and disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/08e953ed2ee54167890462b34ebbf788
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A gene regulatory network to control EMT programs in development and disease

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