A gene regulatory network to control EMT programs in development and disease

A gene regulatory network to control EMT programs in development and disease

EMT is a developmental process that is aberrantly activated in metastasizing cancer cells, but how multiple transcription factors regulate EMT is unclear. Here, the authors uncover a gene regulatory network between Prrx1 and Snail1 that selects EMT mode in developing vertebrates and cancer cells.

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Autores principales: Hassan Fazilaty, Luciano Rago, Khalil Kass Youssef, Oscar H. Ocaña, Francisco Garcia-Asencio, Aida Arcas, Juan Galceran, M. Angela Nieto
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/08e953ed2ee54167890462b34ebbf788
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